Protein kinases and phosphatases

These enzymes phosphorylate or dephosphorylate other proteins. By definition, they use ATP (or GTP) as the phosphoryl group donor (as opposed to phosphotransferases of the phosphotranferase system and the phosphorelay).

Protein kinases

Protein arginine kinases

• McsB

Protein serine kinases

• HprK (has also phosphorylase activity)
• CotH
• PrkC
• PrkD
• RsbT
• RsbW
• SpoIIAB
• YabT

Protein tyrosine kinases (see the Bacterial Protein Tyrosine Kinase Database)

• PtkA
• EpsB: similar to PtkA, but has probably no kinase activity

Protein kinases of two-component systems

• ComP
• DegS
• DesK
• LiaS
• YdfH
• YfiJ
• YhcY
• YvfT
• YxjM
• BceS
• CssS
• NatK
• PhoR
• ResE
• WalK
• YbdK
• YcbM
• YclK
• YkoH
• YrkO
• YvcQ
• YvrG
• YxdK
• CheA
• CitS
• DctS
• GlnK
• MalK
• LytS
• YesM
• YwpD
• KinA
• KinB
• KinC
• KinD
• KinE

Protein phosphatases

Protein arginine phosphatases

• YwlE

Protein serine phosphatases

• PrpC
• RsbP
• RsbU
• RsbX
• SpoIIE

Protein tyrosine phosphatases

• PtpZ
• YfkJ

Protein aspartate phosphatases controlling the phosphorelay

• Spo0E: dephosphorylation of Spo0A
• YisI: dephosphorylation of Spo0A
• YnzD: dephosphorylation of Spo0A
• RapA: dephosphorylation of Spo0F
• RapB: dephosphorylation of Spo0F
• RapE: dephosphorylation of Spo0F
• RapH: dephosphorylation of Spo0F

Related Lists

• phosphoproteins
• protein modification
• two-component systems