PbuX

• Description: xanthine transport in/out via proton symport
  
  

Gene name	pbuX
Synonyms	ypaQ
Essential	no
Product	xanthine permease
Function	xanthine uptake
Metabolic function and regulation of this protein in SubtiPathways: Purine salvage, Nucleotides (regulation)
MW, pI	46 kDa, 8.793
Gene length, protein length	1314 bp, 438 aa
Immediate neighbours	bcsA, xpt
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU22060

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: membrane PubMed

Database entries

• Structure:

• Swiss prot entry: P42086

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: xpt-pbuX PubMed

• Sigma factor:

• Regulation:
  • repressed in the presence of purine nucleotides (PurR) PubMed
  • repressed in the presence of adenine or adenosine (PurR) PubMed
  • induced in the absence of guanine (G-box) PubMed

• Regulatory mechanism:
  • PurR: transcription repression PubMed
  • G-box: transcription termination/ antitermination (riboswitch) PubMed1 PubMed2
  • PurR: transcription repression (molecular inducer: PRPP) PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: