Difference between revisions of "GuaD"

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|style="background:#ABCDEF;" align="center"|'''Function''' || deamination of guanine to xanthine, <br/>purine salvage and interconversion
 
|style="background:#ABCDEF;" align="center"|'''Function''' || deamination of guanine to xanthine, <br/>purine salvage and interconversion
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU13170 guaD]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU13170 guaD]
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/purines_salvage_pathways.html Purine salvage], [http://subtiwiki.uni-goettingen.de/pathways/purines_catabolism.html Purine catabolism], [http://subtiwiki.uni-goettingen.de/pathways/gene_regulation_nucleotides.html Nucleotides (regulation)]'''
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/purines_salvage_pathways.html Purine salvage], [http://subtiwiki.uni-goettingen.de/pathways/purines_catabolism.html Purine catabolism], [http://subtiwiki.uni-goettingen.de/pathways/gene_regulation_nucleotides.html Nucleotides (regulation)]'''
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ykzN]]'', ''[[metE]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ykzN]]'', ''[[metE]]''
 
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB13174&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU13170 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU13170 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU13170 Advanced_DNA]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:guaD_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:guaD_context.gif]]

Revision as of 12:38, 13 May 2013

  • Description: guanine deaminase, general stress protein, important for survival of ethanol stress

Gene name guaD
Synonyms gde, yknA
Essential no
Product guanine deaminase
Function deamination of guanine to xanthine,
purine salvage and interconversion
Gene expression levels in SubtiExpress: guaD
Metabolic function and regulation of this protein in SubtiPathways:
Purine salvage, Purine catabolism, Nucleotides (regulation)
MW, pI 17 kDa, 4.999
Gene length, protein length 468 bp, 156 aa
Immediate neighbours ykzN, metE
Sequences Protein DNA Advanced_DNA
Genetic context
GuaD context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
GuaD expression.png




























Categories containing this gene/protein

biosynthesis/ acquisition of nucleotides, general stress proteins (controlled by SigB)

This gene is a member of the following regulons

PucR regulon, SigB regulon

The gene

Basic information

  • Locus tag: BSU13170

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Guanine + H2O = xanthine + NH3 (according to Swiss-Prot)
  • Protein family: cytidine and deoxycytidylate deaminase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • induced by stress (SigB) PubMed
    • induced in the presence of purine nucleotides (inducer: allantoin) (PucR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

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