Difference between revisions of "GuaC"
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Revision as of 14:28, 16 May 2013
- Description: GMP reductase
Gene name | guaC |
Synonyms | yumD |
Essential | no |
Product | GMP reductase |
Function | purine salvage and interconversion |
Gene expression levels in SubtiExpress: guaC | |
Metabolic function and regulation of this protein in SubtiPathways: Purine synthesis, Nucleotides (regulation) | |
MW, pI | 35 kDa, 6.078 |
Gene length, protein length | 978 bp, 326 aa |
Immediate neighbours | yuzG, paiB |
Sequences | Protein DNA DNA_with_flanks |
Genetic context This image was kindly provided by SubtiList
| |
Expression at a glance PubMed |
Contents
Categories containing this gene/protein
biosynthesis/ acquisition of nucleotides
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU32130
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH (according to Swiss-Prot)
- Protein family: GuaC type 2 subfamily (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure: 1YPF (from Bacillus anthracis, 84% identity, 91% similarity)
- UniProt: O05269
- KEGG entry: [3]
- E.C. number: 1.7.1.7
Additional information
Expression and regulation
- Operon: guaC PubMed
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Lehnik-Habrink M, Schaffer M, Mäder U, Diethmaier C, Herzberg C, Stülke J RNA processing in Bacillus subtilis: identification of targets of the essential RNase Y. Mol Microbiol. 2011 81(6): 1459-1473. PubMed:21815947