FliD

• Description: filament cap, serves as an extracytoplasmic chaperone required for polymerization of flagellin into the helical filament
  
  

Gene name	fliD
Synonyms
Essential	no
Product	extracytoplasmic chaperone required for polymerization of flagellin
Function	motility and chemotaxis
Gene expression levels in SubtiExpress: fliD
Interactions involving this protein in SubtInteract: FliD
MW, pI	54 kDa, 4.804
Gene length, protein length	1494 bp, 498 aa
Immediate neighbours	fliS, yvyC
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

motility and chemotaxis

This gene is a member of the following regulons

SigD regulon

The gene

Basic information

• Locus tag: BSU35340

Phenotypes of a mutant

• the mutation suppresses the mucoid phenotype of motA or motB mutants PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: fliD family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:
  • FlhA-FliD PubMed
  • FliD-FliT PubMed
  • FlhA-(FliD-FliT) PubMed

• Localization: secreted (according to Swiss-Prot), extracellular (no signal peptide) PubMed

Database entries

• Structure:

• UniProt: P39738

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: yvyC-fliD-fliS-fliT PubMed

• Expression browser: fliD PubMed

• Sigma factor: SigD PubMed

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Jia Mun Chan, Sarah B Guttenplan, Daniel B Kearns
Defects in the flagellar motor increase synthesis of poly-γ-glutamate in Bacillus subtilis.
J Bacteriol: 2014, 196(4);740-53
[PubMed:24296669] [WorldCat.org] [DOI] (I p)

Gert Bange, Nico Kümmerer, Christoph Engel, Gunes Bozkurt, Klemens Wild, Irmgard Sinning
FlhA provides the adaptor for coordinated delivery of late flagella building blocks to the type III secretion system.
Proc Natl Acad Sci U S A: 2010, 107(25);11295-300
[PubMed:20534509] [WorldCat.org] [DOI] (I p)

Birgit Voigt, Haike Antelmann, Dirk Albrecht, Armin Ehrenreich, Karl-Heinz Maurer, Stefan Evers, Gerhard Gottschalk, Jan Maarten van Dijl, Thomas Schweder, Michael Hecker
Cell physiology and protein secretion of Bacillus licheniformis compared to Bacillus subtilis.
J Mol Microbiol Biotechnol: 2009, 16(1-2);53-68
[PubMed:18957862] [WorldCat.org] [DOI] (I p)

L Chen, J D Helmann
The Bacillus subtilis sigma D-dependent operon encoding the flagellar proteins FliD, FliS, and FliT.
J Bacteriol: 1994, 176(11);3093-101
[PubMed:8195064] [WorldCat.org] [DOI] (P p)