DctP

• Description: uptake of succinate, fumurate, malate and oxaloacetate via proton symport
  
  

Gene name	dctP
Synonyms	ydbH, dctA
Essential	no
Product	C4-dicarboxylate transport protein
Function	uptake of succinate, fumurate, malate and oxaloacetate
Gene expression levels in SubtiExpress: dctP
Interactions involving this protein in SubtInteract: DctP
Metabolic function and regulation of this protein in SubtiPathways: dctP
MW, pI	45 kDa, 8.668
Gene length, protein length	1263 bp, 421 aa
Immediate neighbours	dctR, ydbI
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transporters/ other, utilization of specific carbon sources, membrane proteins

This gene is a member of the following regulons

CcpA regulon, FsrA regulon

The gene

Basic information

• Locus tag: BSU04470

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • uptake of succinate, fumurate, malate and oxaloacetate via proton symport PubMed
  • acts as co-sensor for DctS PubMed

• Protein family: View classification (according to Swiss-Prot)

• Paralogous protein(s): GltP, GltT

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:
  • DctB-DctS-DctP, sensing complex PubMed

• Localization:
  • cell membrane (according to Swiss-Prot)

Database entries

• Structure: 4KY0 (the glutamate transporter of Thermococcus kodakarensis, 31% identity, 71% similarity) PubMed

• UniProt: P96603

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:
  • dctS-dctR-dctP PubMed
  • dctP PubMed

• Expression browser: dctP PubMed

• Sigma factor:
  • dctP: SigA PubMed

• Regulation:
  • repressed by glucose (6.2-fold) (CcpA) PubMed
  • part of the iron sparing response, strong down-regulation in a fur mutant (Fur, FsrA) PubMed

• Regulatory mechanism:
  • CcpA: transcription repression PubMed
  • Fur: indirect effect via control of fsrA expression PubMed
  • FsrA: translation inhibition PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: