Difference between revisions of "MgsR"
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− | * '''Description:''' transcriptional regulator of a subset of the [[SigB]] general stress regulon <br/><br/> | + | * '''Description:''' transcriptional regulator of a subset of the [[SigB]] general stress regulon, required for protection against oxidative stress <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
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|style="background:#ABCDEF;" align="center"|'''Function''' || controls a subset of general stress genes | |style="background:#ABCDEF;" align="center"|'''Function''' || controls a subset of general stress genes | ||
|- | |- | ||
− | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU24770 mgsR] |
+ | |- | ||
+ | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=MgsR MgsR] | ||
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 14 kDa, 9.28 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 14 kDa, 9.28 | ||
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[trnSL-Gln1]]'', ''[[yqgY]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[trnSL-Gln1]]'', ''[[yqgY]]'' | ||
|- | |- | ||
− | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU24770 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU24770 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU24770 DNA_with_flanks] |
|- | |- | ||
|- | |- | ||
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|colspan="2" | '''Genetic context''' <br/> [[Image:yqgZ_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:yqgZ_context.gif]] | ||
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | ||
+ | |- | ||
+ | |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=mgsR_2564026_2564406_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:mgsR_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU24770]] | ||
|- | |- | ||
|} | |} | ||
__TOC__ | __TOC__ | ||
− | + | <br/><br/><br/><br/> | |
+ | <br/><br/><br/><br/> | ||
+ | <br/><br/><br/><br/> | ||
<br/><br/><br/><br/> | <br/><br/><br/><br/> | ||
= [[Categories]] containing this gene/protein = | = [[Categories]] containing this gene/protein = | ||
{{SubtiWiki category|[[transcription factors and their control]]}}, | {{SubtiWiki category|[[transcription factors and their control]]}}, | ||
− | {{SubtiWiki category|[[general stress proteins (controlled by SigB)]]}} | + | {{SubtiWiki category|[[general stress proteins (controlled by SigB)]]}}, |
+ | {{SubtiWiki category|[[resistance against oxidative and electrophile stress]]}} | ||
= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
− | {{SubtiWiki regulon|[[SigB regulon]]}} | + | {{SubtiWiki regulon|[[SigB regulon]]}}, |
+ | {{SubtiWiki regulon|[[MgsR regulon]]}} | ||
=The gene= | =The gene= | ||
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=== Database entries === | === Database entries === | ||
+ | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU24770&redirect=T BSU24770] | ||
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/yqgZ.html] | * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/yqgZ.html] | ||
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=== Additional information=== | === Additional information=== | ||
− | |||
− | |||
− | |||
=The protein= | =The protein= | ||
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* '''Modification:''' | * '''Modification:''' | ||
+ | ** [[MgsR]] is subject to post-translational redox-sensitive activation by intramolecular disulfide bond formation in response to ethanol stress {{PubMed|22812682}} | ||
* '''Cofactor(s):''' | * '''Cofactor(s):''' | ||
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* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
− | * '''Interactions:''' | + | * '''[[SubtInteract|Interactions]]:''' |
** [[MgsR]]-[[RpoA]] {{PubMed|18643936}} | ** [[MgsR]]-[[RpoA]] {{PubMed|18643936}} | ||
− | * '''Localization:''' | + | * '''[[Localization]]:''' |
=== Database entries === | === Database entries === | ||
+ | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU24770&redirect=T BSU24770] | ||
* '''Structure:''' | * '''Structure:''' | ||
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* '''Operon:''' ''mgsR'' {{PubMed|18643936}} | * '''Operon:''' ''mgsR'' {{PubMed|18643936}} | ||
+ | |||
+ | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=mgsR_2564026_2564406_-1 mgsR] {{PubMed|22383849}} | ||
* '''[[Sigma factor]]:''' [[SigB]] {{PubMed|18643936}} | * '''[[Sigma factor]]:''' [[SigB]] {{PubMed|18643936}} | ||
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* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
− | + | ** MgsR: transcription activation {{PubMed|22812682}} | |
* '''Additional information:''' | * '''Additional information:''' | ||
+ | ** [[MgsR]] is subject to post-translational redox-sensitive activation by intramolecular disulfide bond formation in response to ethanol stress {{PubMed|22812682}} | ||
+ | ** [[MgsR]] is subject to rapid proteolytic degradation by [[ClpX]]-[[ClpP]] and [[ClpC]]-[[ClpP]] {{PubMed|22812682}} | ||
=Biological materials = | =Biological materials = | ||
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=References= | =References= | ||
− | + | <pubmed>18643936, 12107147 15805528 18643936,22812682 22582280</pubmed> | |
− | <pubmed>18643936 | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] |
Latest revision as of 14:13, 2 April 2014
- Description: transcriptional regulator of a subset of the SigB general stress regulon, required for protection against oxidative stress
Gene name | mgsR |
Synonyms | yqgZ |
Essential | no |
Product | transcriptional regulator |
Function | controls a subset of general stress genes |
Gene expression levels in SubtiExpress: mgsR | |
Interactions involving this protein in SubtInteract: MgsR | |
MW, pI | 14 kDa, 9.28 |
Gene length, protein length | 378 bp, 126 aa |
Immediate neighbours | trnSL-Gln1, yqgY |
Sequences | Protein DNA DNA_with_flanks |
Genetic context This image was kindly provided by SubtiList
| |
Expression at a glance PubMed |
Contents
Categories containing this gene/protein
transcription factors and their control, general stress proteins (controlled by SigB), resistance against oxidative and electrophile stress
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU24770
Phenotypes of a mutant
Database entries
- BsubCyc: BSU24770
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: exerts a positive or negative effect on the expression of 53 or 18 stress genes, respectively PubMed
- Protein family: arsC family (according to Swiss-Prot) Arsenate Reductase (ArsC) family, Spx subfamily
- Paralogous protein(s): Spx
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- BsubCyc: BSU24770
- Structure:
- UniProt: P54503
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: mgsR PubMed
- Regulatory mechanism:
- MgsR: transcription activation PubMed
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References