YukB

• Description: membrane FtsK/SpoIIIE-like ATPase, part of the type VII protein secretion system YukD-YukC-YukB-YueB-YueC
  
  

Gene name	yukB
Synonyms
Essential	no
Product	membrane FtsK/SpoIIIE-like ATPase, part of the type VII protein secretion system
Function	export of YukE
Gene expression levels in SubtiExpress: yukB
MW, pI	172 kDa, 5.462
Gene length, protein length	4485 bp, 1495 aa
Immediate neighbours	yueB, yukC
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

protein secretion, membrane proteins

This gene is a member of the following regulons

DegU regulon

The gene

Basic information

• Locus tag: BSU31875

Phenotypes of a mutant

• loss of secretion of YukE PubMed

Database entries

• BsubCyc: BSU31875

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • membrane (according to SwissProt) PubMed
  • cytoplasm (Homogeneous) PubMed

Database entries

• BsubCyc: BSU31875

• Structure:

• UniProt: C0SPA7

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: yukE-yukD-yukC-yukB-yueB-yueC PubMed

• Expression browser: yukB PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • not expressed in the lab strain 168, due to lack of DegU-P PubMed
  • expressed in the stationary phase PubMed

• Regulatory mechanism:
  • DegU-P: transcription activation PubMed

• Additional information:
  • number of protein molecules per cell (complex medium with amino acids, without glucose): 1354 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Roxane Simeone, Daria Bottai, Roland Brosch
ESX/type VII secretion systems and their role in host-pathogen interaction.
Curr Opin Microbiol: 2009, 12(1);4-10
[PubMed:19155186] [WorldCat.org] [DOI] (I p)

Mark J Pallen
The ESAT-6/WXG100 superfamily -- and a new Gram-positive secretion system?
Trends Microbiol: 2002, 10(5);209-12
[PubMed:11973144] [WorldCat.org] [DOI] (P p)