purN
168
phosphoribosylglycinamide formyltransferase, irreversible
Locus
BSU_06510
Molecular weight
21.63 kDa
Isoelectric point
6.18
Function
purine biosynthesis
Product
phosphoribosylglycinamide formyltransferase
Essential
no
E.C.
2.1.2.2
Synonyms
purN
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0299 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
708,010 708,597
The protein
Catalyzed reaction/ biological activity
(6S)-10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide --> (6S)-5,6,7,8-tetrahydrofolate + H+ + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide (according to UniProt)
Protein family
GART family (single member, according to UniProt)
Structure
3P9X (PDB) (from B. halodurans, 51% identity, 70% similarity)
Paralogous protein(s)
Expression and Regulation
Operons
Description
Regulation
expression activated by glucose (4.4 fold) PubMed
Regulatory mechanism
Sigma factors
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Biological materials
Mutant
References
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Time of last update: 2024-12-03 21:28:13
Author of last update: Melvin.boenninger