Difference between revisions of "SrfAA"
| Line 50: | Line 50: | ||
{{SubtiWiki regulon|[[ComA regulon]]}}, | {{SubtiWiki regulon|[[ComA regulon]]}}, | ||
{{SubtiWiki regulon|[[PerR regulon]]}}, | {{SubtiWiki regulon|[[PerR regulon]]}}, | ||
| + | {{SubtiWiki regulon|[[PhoP regulon]]}}, | ||
{{SubtiWiki regulon|[[Spx regulon]]}} | {{SubtiWiki regulon|[[Spx regulon]]}} | ||
| Line 123: | Line 124: | ||
** repressed during hydrogen peroxide stress ([[PerR]]) {{PubMed|16166527}} | ** repressed during hydrogen peroxide stress ([[PerR]]) {{PubMed|16166527}} | ||
** expressed at high cell density ([[ComA]]) {{PubMed|16091051}} | ** expressed at high cell density ([[ComA]]) {{PubMed|16091051}} | ||
| + | ** induced under conditions of phosphate limitation ([[PhoP]]) {{PubMed|25666134}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| + | ** [[PhoP]]: transcription activation {{PubMed|25666134}} | ||
** [[CodY]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/8830686 PubMed] | ** [[CodY]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/8830686 PubMed] | ||
** [[ComA]]: transcription activation {{PubMed|1715856,16091051}} | ** [[ComA]]: transcription activation {{PubMed|1715856,16091051}} | ||
| Line 157: | Line 160: | ||
<pubmed>20735481 </pubmed> | <pubmed>20735481 </pubmed> | ||
==Original publications== | ==Original publications== | ||
| − | <pubmed>8288534,8387999,1938922,16166527,17227471,8825779, 8830686,18763711 17218307, 17190806 1715856 19605685 19826092 12642660 20148996 16091051 20797616 20525796 21821766 23012477 22511326,20817675,15066026 24425772 25448819 </pubmed> | + | <pubmed>8288534,8387999,1938922,16166527,17227471,8825779, 8830686,18763711 17218307, 17190806 1715856 19605685 19826092 12642660 20148996 16091051 20797616 20525796 21821766 23012477 22511326,20817675,15066026 24425772 25448819 25666134</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 13:06, 11 February 2015
- Description: surfactin synthetase / competence
| Gene name | srfAA |
| Synonyms | comL |
| Essential | no |
| Product | surfactin synthetase / competence |
| Function | antibiotic synthesis |
| Gene expression levels in SubtiExpress: srfAA | |
| MW, pI | 401 kDa, 4.871 |
| Gene length, protein length | 10764 bp, 3588 aa |
| Immediate neighbours | hxlR, srfAB |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
miscellaneous metabolic pathways, biosynthesis of antibacterial compounds, membrane proteins, phosphoproteins
This gene is a member of the following regulons
Abh regulon, CodY regulon, ComA regulon, PerR regulon, PhoP regulon, Spx regulon
The gene
Basic information
- Locus tag: BSU03480
Phenotypes of a mutant
- altered cell death pattern in colonies PubMed
- reduced swarming of srfAA mutant of B. subtilis NCIB3610 PubMed
Database entries
- BsubCyc: BSU03480
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
- A mutation was found in this gene after evolution under relaxed selection for sporulation PubMed
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: ATP-dependent AMP-binding enzyme family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification: phosphorylation on Ser-1006 PubMed
- Effectors of protein activity:
- Localization: membrane PubMed
Database entries
- BsubCyc: BSU03480
- Structure:
- UniProt: P27206
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Original publications
