hisG

hisG
168

ATP phosphoribosyltransferase

Locus
BSU_34920
Molecular weight
23.47 kDa
Isoelectric point
4.53
Protein length
Gene length
Function
biosynthesis of histidine
Product
ATP phosphoribosyltransferase
Essential
no
E.C.
2.4.2.17
Synonyms
hisG

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0040 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,587,551  3,588,192
Phenotypes of a mutant
auxotrophic for histidine PubMed
The protein
Catalyzed reaction/ biological activity
PRPP + ATP --> phosphoribosyl-ATP + diphosphate (according to UniProt)
Protein family
ATP phosphoribosyltransferase family (single member, according to UniProt)
Structure
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Description
Regulation
expression during spore germination is strongly reduced under conditions of osmotic stress PubMed
expression depends on functional RnpM PubMed
Regulatory mechanism
RnpM: unknown, PubMed, in rnpM regulon
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hisZhisI

2024-12-07 07:32:25

Jstuelk

113

896e17f5309df81d9427f38fec175515ad428723

B6AAF7601668444EDDC2FE084A87885740B98ACD

Biological materials
Mutant
GP3621 (ΔhisG::aphA3), available in Jörg Stülke's lab
GP3624 (ΔhisG::phleo), available in Jörg Stülke's lab
BKE34920 (hisG::erm  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CTTTGGCATCGCCATTGTGA,  downstream forward: _UP4_GTTGTGGAAGGAGAGACGGC
BKK34920 (hisG::kan  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CTTTGGCATCGCCATTGTGA,  downstream forward: _UP4_GTTGTGGAAGGAGAGACGGC
References
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Time of last update: 2024-12-12 19:53:48

Author of last update: Jstuelk