glnR

glnR
168

transcriptional repressor (MerR family) of the glnR-glnA operon

Locus
BSU_17450
Molecular weight
15.69 kDa
Isoelectric point
9.73
Protein length
Gene length
Function
regulation of glutamine synthesis
Product
transcription repressor (MerR family)
Essential
no
Synonyms
glnR

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0789 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,877,959  1,878,366
The protein
Protein family
HTH merR-type domain (aa 11-79) (according to UniProt)
feedback-inhibited GlnA PubMed
Structure
4R4E (PDB) (the GlnR-DNA complex) PubMed
7TFC (PDB) (the GlnA-GlnR (C tail peptide) complex) PubMed
Effectors of protein activity
activity is enhanced upon interaction of the C-terminal domain with GlnA PubMed
Expression and Regulation
Operons
Genes
Description
Regulation
expressed in the absence of glutamine (GlnR) PubMed
the mRNA is processed between glnR and glnA by RNase Y, this requires the RicA-RicF-RicT complex PubMed
Regulatory mechanism
TnrA: repression, PubMed, in tnrA regulon
GlnR: repression, in complex with GlnA, in glnR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Open in new tab

glnRglnA

2024-12-07 09:08:53

Jstuelk

86

071583dc6a41a10d9b12ab56cf295c4d4fbfe350

168F5BFAABEE27136E7759E8FF655AA525A270D1

Description
Regulation
the mRNA is processed between glnR and glnA by RNase Y, this requires the RicA-RicF-RicT complex PubMed
Open in new tab

ynbAglnA

2024-12-11 02:45:12

Jstuelk

283

d45811f6bc7bef80a041d78aaa209f36dccdee6a

2408FECBCAE7255480B230470AF58DDA9F084F5A

Genes
Description
Regulatory mechanism
TnrA: repression, PubMed, in tnrA regulon
GlnR: repression, in complex with GlnA, in glnR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Open in new tab

glnR

2024-12-13 16:54:55

Jstuelk

62

5d85452d00a4a5ee1c424fb007732e6f9725ac29

8EFC739FE47C5DE47CAAF68DE72A5F61BAB001FA

Additional information
the mRNA is cleaved by RNase III PubMed
Biological materials
Mutant
BP148 (del(''glnR-glnA)::cat''), available in Fabian Commichau's lab
BKE17450 (glnR::erm  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CATCTCAATTTCCTCCTTTT,  downstream forward: _UP4_TAATCCGTTAGCAACTGTTT
BKK17450 (glnR::kan  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CATCTCAATTTCCTCCTTTT,  downstream forward: _UP4_TAATCCGTTAGCAACTGTTT
LacZ fusion
pGP189 (in pAC7), available in Jörg Stülke's lab
Labs working on this gene/protein
Susan Fisher, Boston, USA homepage
References
Reviews
Loading
Original Publications
Loading

641C4BDD9702804642E1753A9C779E80FABB3919

Page visits: 8462

Time of last update: 2024-12-13 11:47:18

Author of last update: Jstuelk