slrR
168
transcriptional activator (Xre family) of competence development and sporulation genes, represses SigD-dependent flagellar genes, antagonist of SlrA and SinR, has LexA-like autocleavage activity
Locus
BSU_34380
Molecular weight
17.43 kDa
Isoelectric point
9.63
Function
regulation of initiation of biofilm formation and of autolysis
Product
transcriptional regulator (Xre family), SlrA antagonist
Essential
no
Synonyms
slrR, yveJ, slr
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1396 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,530,101 3,530,559
Phenotypes of a mutant
smooth colonies on MsGG medium, no biofilm formation PubMed
The protein
Catalyzed reaction/ biological activity
SlrR binds to and inhibits the activity of SlrA, SlrA indirectly stimulates the synthesis of SlrR by interacting with SinR. SlrR can bind to SinR and SinR directly represses the transcription of SlrR. SlrR indirectly derepresses its own gene. The heterocomplex of SlrR-SinR is a repressor of autolysin and motility genes and inhibits the repressor function of SinR. PubMed
autocleavage PubMed
Protein family
HTH cro/C1-type domain (aa 6-61) (according to UniProt)
Sin domain (aa 113-151) (according to UniProt)
Structure
Modification
Effectors of protein activity
Paralogous protein(s)
Expression and Regulation
Operons
Biological materials
Mutant
MGNA-A089 (slr::erm), available at the NBRP B. subtilis, Japan
GP955 (slrR-''pnbA::cat''), available in Jörg Stülke's lab
Two-hybrid system
B. pertussis adenylate cyclase-based bacterial two hybrid system (BACTH), available in Jörg Stülke's lab
References
Reviews
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Original Publications
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Time of last update: 2024-12-13 14:51:56
Author of last update: Jstuelk