Difference between revisions of "MgsR"

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* '''Description:''' transcriptional regulator of a subset of the [[SigB]] general stress regulon <br/><br/>
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* '''Description:''' transcriptional regulator of a subset of the [[SigB]] general stress regulon, required for protection against oxidative stress  <br/><br/>
  
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
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|style="background:#ABCDEF;" align="center"|'''Function''' || controls a subset of general stress genes
 
|style="background:#ABCDEF;" align="center"|'''Function''' || controls a subset of general stress genes
 
|-
 
|-
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/MgsR MgsR]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU24770 mgsR]
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|-
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=MgsR MgsR]
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 14 kDa, 9.28   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 14 kDa, 9.28   
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[trnSL-Gln1]]'', ''[[yqgY]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[trnSL-Gln1]]'', ''[[yqgY]]''
 
|-
 
|-
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB14408&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU24770 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU24770 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU24770 DNA_with_flanks]
 
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|-
 
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  <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
 
  <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
 
|-
 
|-
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|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=mgsR_2564026_2564406_-1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:mgsR_expression.png|500px]]
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|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=mgsR_2564026_2564406_-1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:mgsR_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU24770]]
 
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|-
 
|}
 
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= [[Categories]] containing this gene/protein =
 
= [[Categories]] containing this gene/protein =
 
{{SubtiWiki category|[[transcription factors and their control]]}},
 
{{SubtiWiki category|[[transcription factors and their control]]}},
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{{SubtiWiki category|[[general stress proteins (controlled by SigB)]]}}
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{{SubtiWiki category|[[general stress proteins (controlled by SigB)]]}},
 +
{{SubtiWiki category|[[resistance against oxidative and electrophile stress]]}}
  
 
= This gene is a member of the following [[regulons]] =
 
= This gene is a member of the following [[regulons]] =
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=== Database entries ===
 
=== Database entries ===
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* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU24770&redirect=T BSU24770]
  
 
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/yqgZ.html]
 
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/yqgZ.html]
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=== Database entries ===
 
=== Database entries ===
 +
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU24770&redirect=T BSU24770]
  
 
* '''Structure:'''
 
* '''Structure:'''
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=mgsR_2564026_2564406_-1 mgsR] {{PubMed|22383849}}
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=mgsR_2564026_2564406_-1 mgsR] {{PubMed|22383849}}
  
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* '''Sigma factor:''' [[SigB]] {{PubMed|18643936}}
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* '''[[Sigma factor]]:''' [[SigB]] {{PubMed|18643936}}
  
 
* '''Regulation:'''  
 
* '''Regulation:'''  
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=References=
 
=References=
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'''Additional publications:''' {{PubMed|22812682}}
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<pubmed>18643936, 12107147 15805528 18643936,22812682 22582280</pubmed>
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<pubmed>18643936, 12107147 15805528 18643936, </pubmed>
 
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Latest revision as of 14:13, 2 April 2014

  • Description: transcriptional regulator of a subset of the SigB general stress regulon, required for protection against oxidative stress

Gene name mgsR
Synonyms yqgZ
Essential no
Product transcriptional regulator
Function controls a subset of general stress genes
Gene expression levels in SubtiExpress: mgsR
Interactions involving this protein in SubtInteract: MgsR
MW, pI 14 kDa, 9.28
Gene length, protein length 378 bp, 126 aa
Immediate neighbours trnSL-Gln1, yqgY
Sequences Protein DNA DNA_with_flanks
Genetic context
YqgZ context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
MgsR expression.png

















Categories containing this gene/protein

transcription factors and their control, general stress proteins (controlled by SigB), resistance against oxidative and electrophile stress

This gene is a member of the following regulons

SigB regulon, MgsR regulon

The gene

Basic information

  • Locus tag: BSU24770

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: exerts a positive or negative effect on the expression of 53 or 18 stress genes, respectively PubMed
  • Protein family: arsC family (according to Swiss-Prot) Arsenate Reductase (ArsC) family, Spx subfamily
  • Paralogous protein(s): Spx

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
    • MgsR is subject to post-translational redox-sensitive activation by intramolecular disulfide bond formation in response to ethanol stress PubMed
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
    • MgsR: transcription activation PubMed
  • Additional information:
    • MgsR is subject to post-translational redox-sensitive activation by intramolecular disulfide bond formation in response to ethanol stress PubMed
    • MgsR is subject to rapid proteolytic degradation by ClpX-ClpP and ClpC-ClpP PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

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