Difference between revisions of "MgsR"
(43 intermediate revisions by 5 users not shown) | |||
Line 1: | Line 1: | ||
− | * '''Description:''' transcriptional regulator of a subset of the SigB general stress regulon <br/><br/> | + | * '''Description:''' transcriptional regulator of a subset of the [[SigB]] general stress regulon, required for protection against oxidative stress <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
Line 13: | Line 13: | ||
|- | |- | ||
|style="background:#ABCDEF;" align="center"|'''Function''' || controls a subset of general stress genes | |style="background:#ABCDEF;" align="center"|'''Function''' || controls a subset of general stress genes | ||
+ | |- | ||
+ | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU24770 mgsR] | ||
+ | |- | ||
+ | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=MgsR MgsR] | ||
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 14 kDa, 9.28 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 14 kDa, 9.28 | ||
Line 18: | Line 22: | ||
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 378 bp, 126 aa | |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 378 bp, 126 aa | ||
|- | |- | ||
− | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || | + | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[trnSL-Gln1]]'', ''[[yqgY]]'' |
+ | |- | ||
+ | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU24770 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU24770 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU24770 DNA_with_flanks] | ||
+ | |- | ||
|- | |- | ||
− | |||
− | |||
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:yqgZ_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:yqgZ_context.gif]] | ||
+ | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | ||
+ | |- | ||
+ | |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=mgsR_2564026_2564406_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:mgsR_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU24770]] | ||
|- | |- | ||
|} | |} | ||
__TOC__ | __TOC__ | ||
+ | <br/><br/><br/><br/> | ||
+ | <br/><br/><br/><br/> | ||
+ | <br/><br/><br/><br/> | ||
+ | <br/><br/><br/><br/> | ||
− | + | = [[Categories]] containing this gene/protein = | |
+ | {{SubtiWiki category|[[transcription factors and their control]]}}, | ||
+ | {{SubtiWiki category|[[general stress proteins (controlled by SigB)]]}}, | ||
+ | {{SubtiWiki category|[[resistance against oxidative and electrophile stress]]}} | ||
+ | |||
+ | = This gene is a member of the following [[regulons]] = | ||
+ | {{SubtiWiki regulon|[[SigB regulon]]}}, | ||
+ | {{SubtiWiki regulon|[[MgsR regulon]]}} | ||
=The gene= | =The gene= | ||
Line 35: | Line 54: | ||
=== Basic information === | === Basic information === | ||
− | * ''' | + | * '''Locus tag:''' BSU24770 |
===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
=== Database entries === | === Database entries === | ||
+ | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU24770&redirect=T BSU24770] | ||
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/yqgZ.html] | * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/yqgZ.html] | ||
Line 46: | Line 66: | ||
=== Additional information=== | === Additional information=== | ||
− | |||
=The protein= | =The protein= | ||
Line 52: | Line 71: | ||
=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
− | * '''Catalyzed reaction/ biological activity:''' exerts a positive or negative | + | * '''Catalyzed reaction/ biological activity:''' exerts a positive or negative effect on the expression of 53 or 18 stress genes, respectively [http://www.ncbi.nlm.nih.gov/sites/entrez/18643936 PubMed] |
− | * '''Protein family:''' Arsenate Reductase (ArsC) family, Spx subfamily | + | * '''Protein family:''' arsC family (according to Swiss-Prot) Arsenate Reductase (ArsC) family, Spx subfamily |
* '''Paralogous protein(s):''' [[Spx]] | * '''Paralogous protein(s):''' [[Spx]] | ||
Line 65: | Line 84: | ||
* '''Modification:''' | * '''Modification:''' | ||
+ | ** [[MgsR]] is subject to post-translational redox-sensitive activation by intramolecular disulfide bond formation in response to ethanol stress {{PubMed|22812682}} | ||
* '''Cofactor(s):''' | * '''Cofactor(s):''' | ||
Line 70: | Line 90: | ||
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
− | * '''Interactions:''' | + | * '''[[SubtInteract|Interactions]]:''' |
+ | ** [[MgsR]]-[[RpoA]] {{PubMed|18643936}} | ||
− | * '''Localization:''' | + | * '''[[Localization]]:''' |
=== Database entries === | === Database entries === | ||
+ | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU24770&redirect=T BSU24770] | ||
* '''Structure:''' | * '''Structure:''' | ||
− | * ''' | + | * '''UniProt:''' [http://www.uniprot.org/uniprot/P54503 P54503] |
− | * '''KEGG entry:''' | + | * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU24770] |
* '''E.C. number:''' | * '''E.C. number:''' | ||
Line 88: | Line 110: | ||
=Expression and regulation= | =Expression and regulation= | ||
− | * '''Operon:''' | + | * '''Operon:''' ''mgsR'' {{PubMed|18643936}} |
+ | |||
+ | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=mgsR_2564026_2564406_-1 mgsR] {{PubMed|22383849}} | ||
− | * '''Sigma factor:''' [[SigB]] | + | * '''[[Sigma factor]]:''' [[SigB]] {{PubMed|18643936}} |
− | * '''Regulation:''' | + | * '''Regulation:''' |
+ | ** repressed by casamino acids [http://www.ncbi.nlm.nih.gov/pubmed/12107147 PubMed] | ||
+ | ** induced by stress ([[SigB]]) {{PubMed|15805528,18643936}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
− | + | ** MgsR: transcription activation {{PubMed|22812682}} | |
* '''Additional information:''' | * '''Additional information:''' | ||
+ | ** [[MgsR]] is subject to post-translational redox-sensitive activation by intramolecular disulfide bond formation in response to ethanol stress {{PubMed|22812682}} | ||
+ | ** [[MgsR]] is subject to rapid proteolytic degradation by [[ClpX]]-[[ClpP]] and [[ClpC]]-[[ClpP]] {{PubMed|22812682}} | ||
=Biological materials = | =Biological materials = | ||
Line 117: | Line 145: | ||
=References= | =References= | ||
+ | <pubmed>18643936, 12107147 15805528 18643936,22812682 22582280</pubmed> | ||
− | + | [[Category:Protein-coding genes]] | |
− |
Latest revision as of 14:13, 2 April 2014
- Description: transcriptional regulator of a subset of the SigB general stress regulon, required for protection against oxidative stress
Gene name | mgsR |
Synonyms | yqgZ |
Essential | no |
Product | transcriptional regulator |
Function | controls a subset of general stress genes |
Gene expression levels in SubtiExpress: mgsR | |
Interactions involving this protein in SubtInteract: MgsR | |
MW, pI | 14 kDa, 9.28 |
Gene length, protein length | 378 bp, 126 aa |
Immediate neighbours | trnSL-Gln1, yqgY |
Sequences | Protein DNA DNA_with_flanks |
Genetic context This image was kindly provided by SubtiList
| |
Expression at a glance PubMed |
Contents
Categories containing this gene/protein
transcription factors and their control, general stress proteins (controlled by SigB), resistance against oxidative and electrophile stress
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU24770
Phenotypes of a mutant
Database entries
- BsubCyc: BSU24770
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: exerts a positive or negative effect on the expression of 53 or 18 stress genes, respectively PubMed
- Protein family: arsC family (according to Swiss-Prot) Arsenate Reductase (ArsC) family, Spx subfamily
- Paralogous protein(s): Spx
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- BsubCyc: BSU24770
- Structure:
- UniProt: P54503
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: mgsR PubMed
- Regulatory mechanism:
- MgsR: transcription activation PubMed
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References