nrdF
168
ribonucleoside-diphosphate reductase (beta subunit)
Locus
BSU_17390
Molecular weight
38.22 kDa
Isoelectric point
4.66
Function
synthesis of deoxyribonucleoside triphosphates
Product
ribonucleoside-diphosphate reductase (beta subunit)
Essential
yes
E.C.
1.17.4.1
Synonyms
nrdF
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0208 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
The protein
Catalyzed reaction/ biological activity
[thioredoxin]-disulfide + 2'-deoxyribonucleoside 5'-diphosphate + H2O --> [thioredoxin]-dithiol + ribonucleoside 5'-diphosphate (according to UniProt)
required for stationary-phase mutagenesis PubMed
Protein family
ribonucleoside diphosphate reductase small chain family (with YosP, according to UniProt)
dimanganic-tyrosyl radical (MnIII2-Y•) cofactor PubMed
Structure
Effectors of protein activity
Paralogous protein(s)
Expression and Regulation
Operons
Biological materials
Expression vectors
pGP2894: expression of Strep-nrdF by pGP380 in B. subtilis suitable for SPINE, available in Jörg Stülke's lab
Labs working on this gene/protein
Elisabeth Härtig, Braunschweig, Germany Homepage
References
Reviews
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Original Publications
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Page visits: 3030
Time of last update: 2024-12-12 12:22:56
Author of last update: Jstuelk