PdxK

• Description: pyridoxine, pyridoxal, and pyridoxamine kinase
  
  

Gene name	pdxK
Synonyms	ywdB, ipa-52r, thiD
Essential	no
Product	pyridoxine, pyridoxal, and pyridoxamine kinase
Function	biosynthesis of pyridoxal phosphate
MW, pI	28 kDa, 4.922
Gene length, protein length	813 bp, 271 aa
Immediate neighbours	ywdC, ywdA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

biosynthesis of cofactors

The gene

Basic information

• Locus tag: BSU38020

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine (according to Swiss-Prot)

• Protein family: thiD family (according to Swiss-Prot)

• Paralogous protein(s): ThiD

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 2IB5

• UniProt: P39610

• KEGG entry: [3]

• E.C. number: 2.7.4.7

Additional information

• subject to Clp-dependent proteolysis upon glucose starvation PubMed

Expression and regulation

• Operon: pdxK PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information: subject to Clp-dependent proteolysis upon glucose starvation PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: