Difference between revisions of "HutI"

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|style="background:#ABCDEF;" align="center"|'''Function''' || histidine utilization  
 
|style="background:#ABCDEF;" align="center"|'''Function''' || histidine utilization  
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU39370 hutI]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU39370 hutI]
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/histidine.html His]'''
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/histidine.html His]'''
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[hutU]]'', ''[[hutG]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[hutU]]'', ''[[hutG]]''
 
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB15973&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU39370 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU39370 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU39370 Advanced_DNA]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:hutI_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:hutI_context.gif]]

Revision as of 14:14, 13 May 2013

  • Description: imidazolone-5-propionate hydrolase

Gene name hutI
Synonyms
Essential no
Product imidazolone-5-propionate hydrolase
Function histidine utilization
Gene expression levels in SubtiExpress: hutI
Metabolic function and regulation of this protein in SubtiPathways:
His
MW, pI 45 kDa, 5.215
Gene length, protein length 1263 bp, 421 aa
Immediate neighbours hutU, hutG
Sequences Protein DNA Advanced_DNA
Genetic context
HutI context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
HutI expression.png



















Categories containing this gene/protein

utilization of amino acids

This gene is a member of the following regulons

CcpA regulon, CodY regulon, HutP regulon

The gene

Basic information

  • Locus tag: BSU39370

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+ (according to Swiss-Prot)
  • Protein family: hutI family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • repressed by glucose (CcpA) PubMed
    • induced by histidine (HutP) PubMed
    • repressed during growth in the presence of branched chain amino acids (CodY) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews


Original publications

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