Difference between revisions of "AlkA"
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= [[Categories]] containing this gene/protein = | = [[Categories]] containing this gene/protein = | ||
| − | {{SubtiWiki category|[[DNA repair/ recombination]]}} | + | {{SubtiWiki category|[[DNA repair/ recombination]]}}, |
| + | {{SubtiWiki category|[[prophage 1]]}} | ||
= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
| Line 106: | Line 107: | ||
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=alkA_202547_203458_-1 alkA] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=alkA_202547_203458_-1 alkA] {{PubMed|22383849}} | ||
| − | * '''Sigma factor:''' [[SigA]] {{PubMed|8376346}} | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|8376346}} |
* '''Regulation:''' | * '''Regulation:''' | ||
Revision as of 11:23, 11 September 2013
- Description: DNA-3-methyladenine glycosylase
| Gene name | alkA |
| Synonyms | |
| Essential | no |
| Product | DNA-3-methyladenine glycosylase |
| Function | adaptive response to alkylative DNA damage |
| Gene expression levels in SubtiExpress: alkA | |
| MW, pI | 35 kDa, 8.147 |
| Gene length, protein length | 909 bp, 303 aa |
| Immediate neighbours | glmS, adaA |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
DNA repair/ recombination, prophage 1
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU01800
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine (according to Swiss-Prot)
- Protein family: alkylbase DNA glycosidase alkA family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: P37878
- KEGG entry: [3]
- E.C. number: 3.2.2.21
Additional information
Expression and regulation
- Regulation:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
F Morohoshi, K Hayashi, N Munkata
Bacillus subtilis alkA gene encoding inducible 3-methyladenine DNA glycosylase is adjacent to the ada operon.
J Bacteriol: 1993, 175(18);6010-7
[PubMed:8376346]
[WorldCat.org]
[DOI]
(P p)
