YxdK

• Description: two-component sensor kinase, regulation of the ABC transporter YxdL-YxdM in response to the cationic antimicrobial peptide, LL-37
  
  

Gene name	yxdK
Synonyms
Essential	no
Product	two-component sensor kinase
Function	resistance against toxic peptides
Gene expression levels in SubtiExpress: yxdK
Interactions involving this protein in SubtInteract: YxdK
MW, pI	37 kDa, 6.226
Gene length, protein length	975 bp, 325 aa
Immediate neighbours	yxdL, yxdJ
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

protein modification, transcription factors and their control, resistance against toxins/ antibiotics, membrane proteins, phosphoproteins

The gene

Basic information

• Locus tag: BSU39650

Database entries

• BsubCyc: BSU39650

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: autophosphorylation, phosphorylation of YxdJ

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains: two transmembrane segments, C-terminal histidine phosphotransferase domain

• Modification: autophosphorylation on a His residue

• Cofactor(s):

• Effectors of protein activity:

• Interactions: YxdK-YxdJ

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• BsubCyc: BSU39650

• Structure:

• UniProt: P42422

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: yxdJ-yxdK PubMed

• Expression browser: yxdK PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed