Difference between revisions of "AbrB"
| Line 80: | Line 80: | ||
* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' | + | * '''[[Domains]]:''' |
* '''Modification:''' phosphorylated on Ser-86 {{PubMed|20509597}} | * '''Modification:''' phosphorylated on Ser-86 {{PubMed|20509597}} | ||
| − | * ''' | + | * '''[[Cofactors]]:''' |
* '''Effectors of protein activity:''' interaction with [[AbbA]] results in inactivation of AbrB [http://www.ncbi.nlm.nih.gov/sites/entrez/18840696 PubMed] | * '''Effectors of protein activity:''' interaction with [[AbbA]] results in inactivation of AbrB [http://www.ncbi.nlm.nih.gov/sites/entrez/18840696 PubMed] | ||
* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
| − | ** [[AbrB]] | + | ** [[AbbA]]-[[AbrB]], [[AbbA]] binds the N-terminal DNA-binding domain of [[AbrB]] {{PubMed|24534728,18840696}} |
** [[AbrB]]-[[AbrB]] {{PubMed|20817675}} | ** [[AbrB]]-[[AbrB]] {{PubMed|20817675}} | ||
** [[AbrB]]-[[Abh]] {{PubMed|20817675}} | ** [[AbrB]]-[[Abh]] {{PubMed|20817675}} | ||
| Line 97: | Line 97: | ||
=== Database entries === | === Database entries === | ||
| − | * '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=1Z0R 1Z0R] (N-terminal DNA recognition domain), | + | * '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=1Z0R 1Z0R] (N-terminal DNA recognition domain), [http://www.ncbi.nlm.nih.gov/sites/entrez/16223496 PubMed] |
* '''UniProt:''' [http://www.uniprot.org/uniprot/P08874 P08874] | * '''UniProt:''' [http://www.uniprot.org/uniprot/P08874 P08874] | ||
Revision as of 08:08, 19 February 2014
- Description: transcriptional regulator of transition state genes
| Gene name | abrB |
| Synonyms | cpsX, tolB |
| Essential | no |
| Product | transcriptional regulator |
| Function | regulation of gene expression during the transition from growth to stationary phase |
| Gene expression levels in SubtiExpress: abrB | |
| Interactions involving this protein in SubtInteract: AbrB | |
| Metabolic function and regulation of this protein in SubtiPathways: abrB | |
| MW, pI | 10 kDa, 6.57 |
| Gene length, protein length | 282 bp, 94 aa |
| Immediate neighbours | yabC, metS |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The AbrB regulon
The gene
Basic information
- Locus tag: BSU00370
Phenotypes of a mutant
No swarming motility on B medium. PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
Extended information on the protein
- Kinetic information:
- Modification: phosphorylated on Ser-86 PubMed
Database entries
- UniProt: P08874
- KEGG entry: [3]
Additional information
Expression and regulation
- Operon: abrB PubMed
- Regulation: expressed at the onset of stationary phase PubMed
- Additional information:
Biological materials
- Mutant: TT731 (aphA3)
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system: B. pertussis adenylate cyclase-based bacterial two hybrid system (BACTH), available in Stülke lab
- Antibody:
Labs working on this gene/protein
Richard Losick, Harvard Univ., Cambridge, USA homepage
Mark Strauch, Baltimore, USA homepage
Your additional remarks
References
Reviews
The AbrB regulon:
Other original publications
