SigG

• Description: RNA polymerase sporulation forespore-specific (late) sigma factor SigG
  
  

Gene name	sigG
Synonyms	spoIIIG
Essential	no
Product	RNA polymerase sporulation forespore-specific (late) sigma factor SigG
Function	transcription of sporulation genes (late forespore)
Gene expression levels in SubtiExpress: sigG
Interactions involving this protein in SubtInteract: SigG
MW, pI	29 kDa, 5.496
Gene length, protein length	780 bp, 260 aa
Immediate neighbours	sigE, ylmA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription, sigma factors and their control, sporulation proteins

This gene is a member of the following regulons

AbrB regulon, SigF regulon, SigG regulon, SinR regulon, Spo0A regulon

The gene

Basic information

• Locus tag: BSU15330

Database entries

• BsubCyc: BSU15330

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: sigma-70 factor family (according to Swiss-Prot)

• Paralogous protein(s): SigF

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:
  • Gin inhibits SigG activity PubMed
  • the activity of SigG-containing RNA polymerase is modulated by YlyA PubMed

• Interactions:
  • SigG-RpoB-RpoC
  • CsfB-SigG PubMed
  • SpoIIAB-SigG PubMed

• Localization:

Database entries

• BsubCyc: BSU15330

• Structure:

• UniProt: P19940

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • spoIIGA-sigE-sigG PubMed
  • sigG PubMed

• Expression browser: sigG PubMed

• Sigma factor:
  • spoIIGA: SigA PubMed
  • sigG: SigF, SigG PubMed

• Regulation:
  • spoIIGA: expressed under conditions that trigger sporulation (Spo0A) PubMed
  • sigG: expressed during sporulation (SigF, SigG) PubMed
  • the mRNA accumulates in a ymdB mutant PubMed

• Regulatory mechanism:
  • repression by SinR
  • Spo0A: transcription activation PubMed
  • AbrB: transcription repression PubMed

• Additional information:
  • the mRNA half-life is about 2.6 min PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Charles Moran, Emory University, NC, USA homepage