Difference between revisions of "SirA"
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| − | * '''Description:''' | + | * '''Description:''' sporulation protein, inhibits DNA replication <br/><br/> |
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
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| − | |style="background:#ABCDEF;" align="center"| '''Product''' || | + | |style="background:#ABCDEF;" align="center"| '''Product''' || inhibitor of DNA replication |
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| − | |style="background:#ABCDEF;" align="center"|'''Function''' || | + | |style="background:#ABCDEF;" align="center"|'''Function''' || control of chromosome copy number |
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 17 kDa, 7.353 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 17 kDa, 7.353 | ||
Revision as of 11:54, 7 April 2009
- Description: sporulation protein, inhibits DNA replication
| Gene name | sirA |
| Synonyms | yneE, yoxF |
| Essential | no |
| Product | inhibitor of DNA replication |
| Function | control of chromosome copy number |
| MW, pI | 17 kDa, 7.353 |
| Gene length, protein length | 444 bp, 148 aa |
| Immediate neighbours | tkt, yneF |
| Gene sequence (+200bp) | Protein sequence |
Genetic context 
This image was kindly provided by SubtiList
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Contents
The gene
yneE was renamed to sirA.
Basic information
- Coordinates:
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- Swiss prot entry:
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
sirA (sporulation inhibitor of replication) is activated by Spo0A~P and inhibits DNA replication during sporulation.
References
- Rahn-Lee L, Gorbatyuk B, Skovgaard O & Losick R.(2009) The Conserved Sporulation Protein YneE inhibits DNA replication in Bacillus subtilis J Bact. volume: page-page. PubMed
