Difference between revisions of "RnpB"
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| − | * '''Description:''' RNA component of RNase P <br/><br/> | + | * '''Description:''' RNA component of [[RNase]] P <br/><br/> |
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Product''' || RNA component of ribonuclease P <br/>(RNase P) (catalytic subunit, ribozyme) | + | |style="background:#ABCDEF;" align="center"| '''Product''' || RNA component of ribonuclease P <br/>([[RNase]] P) (catalytic subunit, ribozyme) |
|- | |- | ||
|style="background:#ABCDEF;" align="center"|'''Function''' || cleavage of precursor sequences <br/>from the 5' ends of pre-tRNAs | |style="background:#ABCDEF;" align="center"|'''Function''' || cleavage of precursor sequences <br/>from the 5' ends of pre-tRNAs | ||
Revision as of 11:09, 3 November 2009
- Description: RNA component of RNase P
| Gene name | rnpB |
| Synonyms | rnaP |
| Essential | no |
| Product | RNA component of ribonuclease P (RNase P) (catalytic subunit, ribozyme) |
| Function | cleavage of precursor sequences from the 5' ends of pre-tRNAs |
| Gene length | 401 bp |
| Immediate neighbours | ypsC, ypsB |
| Gene sequence (+200bp) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag:
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
The RNA
- Biological activity:
- RNA family:
- interaction: RnpA-RnpB
Additional information
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/RNA
Roland Hartmann, Marburg University, Germany homepage
Your additional remarks
References
Stefanie A Mortimer, Kevin M Weeks
C2'-endo nucleotides as molecular timers suggested by the folding of an RNA domain.
Proc Natl Acad Sci U S A: 2009, 106(37);15622-7
[PubMed:19717440]
[WorldCat.org]
[DOI]
(I p)
John Hsieh, Carol A Fierke
Conformational change in the Bacillus subtilis RNase P holoenzyme--pre-tRNA complex enhances substrate affinity and limits cleavage rate.
RNA: 2009, 15(8);1565-77
[PubMed:19549719]
[WorldCat.org]
[DOI]
(I p)
Barbara Wegscheid, Roland K Hartmann
In vivo and in vitro investigation of bacterial type B RNase P interaction with tRNA 3'-CCA.
Nucleic Acids Res: 2007, 35(6);2060-73
[PubMed:17355991]
[WorldCat.org]
[DOI]
(I p)
Barbara Wegscheid, Ciarán Condon, Roland K Hartmann
Type A and B RNase P RNAs are interchangeable in vivo despite substantial biophysical differences.
EMBO Rep: 2006, 7(4);411-7
[PubMed:16470227]
[WorldCat.org]
[DOI]
(P p)
Christoph Rox, Ralph Feltens, Thomas Pfeiffer, Roland K Hartmann
Potential contact sites between the protein and RNA subunit in the Bacillus subtilis RNase P holoenzyme.
J Mol Biol: 2002, 315(4);551-60
[PubMed:11812129]
[WorldCat.org]
[DOI]
(P p)
A Hansen, T Pfeiffer, T Zuleeg, S Limmer, J Ciesiolka, R Feltens, R K Hartmann
Exploring the minimal substrate requirements for trans-cleavage by RNase P holoenzymes from Escherichia coli and Bacillus subtilis.
Mol Microbiol: 2001, 41(1);131-43
[PubMed:11454206]
[WorldCat.org]
[DOI]
(P p)
J M Warnecke, R Held, S Busch, R K Hartmann
Role of metal ions in the hydrolysis reaction catalyzed by RNase P RNA from Bacillus subtilis.
J Mol Biol: 1999, 290(2);433-45
[PubMed:10390342]
[WorldCat.org]
[DOI]
(P p)
