Difference between revisions of "RecA"
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| − | * '''Description:''' multifunctional protein involved in homologous recombination and DNA repair (LexA-autocleavage) <br/><br/> | + | * '''Description:''' multifunctional protein involved in homologous recombination and DNA repair ([[LexA]]-autocleavage) <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
| Line 10: | Line 10: | ||
|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Product''' || multifunctional protein involved in homologous <br/>recombination and DNA repair (LexA-autocleavage) | + | |style="background:#ABCDEF;" align="center"| '''Product''' || multifunctional protein involved in homologous <br/>recombination and DNA repair ([[LexA]]-autocleavage) |
|- | |- | ||
|style="background:#ABCDEF;" align="center"|'''Function''' || homologous recombination, DNA repair | |style="background:#ABCDEF;" align="center"|'''Function''' || homologous recombination, DNA repair | ||
| Line 93: | Line 93: | ||
* '''Regulation:''' | * '''Regulation:''' | ||
| − | ** induced by DNA damage ([[LexA]]) {{PubMed|8226626,11555642}} | + | ** induced by DNA damage ([[LexA]]) {{PubMed|8226626,11555642,16267290}} |
** induced by conditions that trigger development of genetic competence ([[ComK]]) {{PubMed|7690748}} | ** induced by conditions that trigger development of genetic competence ([[ComK]]) {{PubMed|7690748}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| − | ** [[LexA]]: transcription repression {{PubMed|8226626,11555642}} | + | ** [[LexA]]: transcription repression {{PubMed|8226626,11555642,16267290}} |
** [[ComK]]: transcription activation {{PubMed|7690748}} | ** [[ComK]]: transcription activation {{PubMed|7690748}} | ||
| Line 126: | Line 126: | ||
<pubmed> 14527291 12045091 10506835 14616075 </pubmed> | <pubmed> 14527291 12045091 10506835 14616075 </pubmed> | ||
==Original publications== | ==Original publications== | ||
| − | <pubmed>11814663,16061691,19060143,17803906,16024744,17630974,8226626,11555642, 16479537 19730681 7690748 17229847 </pubmed> | + | <pubmed>11814663,16061691,19060143,17803906,16024744,17630974,8226626,11555642, 16479537 19730681 7690748 17229847,16267290 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 20:08, 4 May 2010
- Description: multifunctional protein involved in homologous recombination and DNA repair (LexA-autocleavage)
| Gene name | recA |
| Synonyms | recE |
| Essential | no |
| Product | multifunctional protein involved in homologous recombination and DNA repair (LexA-autocleavage) |
| Function | homologous recombination, DNA repair |
| MW, pI | 37 kDa, 4.883 |
| Gene length, protein length | 1041 bp, 347 aa |
| Immediate neighbours | cinA, pbpX |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU16940
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: recA family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cytoplasm (according to Swiss-Prot), Nucleoid (Mid-cell) PubMed
Database entries
- Structure:
- UniProt: P16971
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: recA PubMed
- Regulation:
- Additional information:
Biological materials
- Mutant: IRN444 (cat), available in the Stülke lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Peter Graumann, Freiburg University, Germany homepage
Your additional remarks
References
Reviews
Justin Courcelle, Philip C Hanawalt
RecA-dependent recovery of arrested DNA replication forks.
Annu Rev Genet: 2003, 37;611-46
[PubMed:14616075]
[WorldCat.org]
[DOI]
(P p)
Michael M Cox
The bacterial RecA protein as a motor protein.
Annu Rev Microbiol: 2003, 57;551-77
[PubMed:14527291]
[WorldCat.org]
[DOI]
(P p)
Shelley L Lusetti, Michael M Cox
The bacterial RecA protein and the recombinational DNA repair of stalled replication forks.
Annu Rev Biochem: 2002, 71;71-100
[PubMed:12045091]
[WorldCat.org]
[DOI]
(P p)
M M Cox
Recombinational DNA repair in bacteria and the RecA protein.
Prog Nucleic Acid Res Mol Biol: 1999, 63;311-66
[PubMed:10506835]
[WorldCat.org]
[DOI]
(P p)
Original publications
