Difference between revisions of "PerR"

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= Categories containing this gene/protein =
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{{SubtiWiki category|[[transcription factors and their control]]}},
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{{SubtiWiki category|[[resistance against oxidative and electrophile stress]]}}
 
=The protein=
 
=The protein=
  

Revision as of 18:44, 30 November 2010

  • Description: transcriptional repressor of the peroxide regulon

Gene name perR
Synonyms ygaG
Essential no
Product transcriptional repressor
Function regulation of the response to peroxide
Metabolic function and regulation of this protein in SubtiPathways:
Stress
MW, pI 16 kDa, 5.888
Gene length, protein length 435 bp, 145 aa
Immediate neighbours ygaF, ygzB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
PerR context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU08730

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

Categories containing this gene/protein

transcription factors and their control, resistance against oxidative and electrophile stress

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: Fur family (according to Swiss-Prot)
  • Paralogous protein(s): Zur, Fur

Genes repressed by PerR

ahpC-ahpF PubMed, zosA

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: selective metal catalyzed oxidation of two histidine residues of the regulatory site results in induction (loss of DNA-binding activity) PubMed
  • Cofactor(s): contains an iron-sulfur cluster
  • Effectors of protein activity:
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • negative autoregulation PubMed
    • induced in the presence of hydrogen peroxide (PerR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage

Your additional remarks

References

Reviews


Original Publications


PubMed