Difference between revisions of "PerR"
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+ | = Categories containing this gene/protein = | ||
+ | {{SubtiWiki category|[[transcription factors and their control]]}}, | ||
+ | {{SubtiWiki category|[[resistance against oxidative and electrophile stress]]}} | ||
=The protein= | =The protein= | ||
Revision as of 18:44, 30 November 2010
- Description: transcriptional repressor of the peroxide regulon
Gene name | perR |
Synonyms | ygaG |
Essential | no |
Product | transcriptional repressor |
Function | regulation of the response to peroxide |
Metabolic function and regulation of this protein in SubtiPathways: Stress | |
MW, pI | 16 kDa, 5.888 |
Gene length, protein length | 435 bp, 145 aa |
Immediate neighbours | ygaF, ygzB |
Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context This image was kindly provided by SubtiList
|
Contents
The gene
Basic information
- Locus tag: BSU08730
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
Categories containing this gene/protein
transcription factors and their control, resistance against oxidative and electrophile stress
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: Fur family (according to Swiss-Prot)
Genes repressed by PerR
Extended information on the protein
- Kinetic information:
- Domains:
- Modification: selective metal catalyzed oxidation of two histidine residues of the regulatory site results in induction (loss of DNA-binding activity) PubMed
- Cofactor(s): contains an iron-sulfur cluster
- Effectors of protein activity:
- Interactions:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- UniProt: P71086
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: perR PubMed
- Regulation:
- Additional information:
Biological materials
- Mutant: HB0509 (spc), available in John Helmann's and Jörg Stülke's labs, also GP868 (fur::mls, perR::spc).
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
John Helmann, Cornell University, USA Homepage
Your additional remarks
References
Reviews
Original Publications