Difference between revisions of "PgcA"

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= [[Categories]] containing this gene/protein =
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{{SubtiWiki category|[[cell wall synthesis]]}},
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{{SubtiWiki category|[[lipid metabolism/ other]]}},
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{{SubtiWiki category|[[phosphoproteins]]}}
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=The gene=
 
=The gene=
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= Categories containing this gene/protein =
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{{SubtiWiki category|[[cell wall synthesis]]}},
 
{{SubtiWiki category|[[lipid metabolism/ other]]}},
 
{{SubtiWiki category|[[phosphoproteins]]}}
 
 
=The protein=
 
=The protein=
  

Revision as of 18:00, 8 December 2010

  • Description: alpha-phosphoglucomutase, required for UDP-glucose synthesis, inhibits FtsZ ring assembly (indirect effect due to a defect in UDP-glucose synthesis)

Gene name pgcA
Synonyms yhxB, gtaC, gtaE
Essential no
Product alpha-phosphoglucomutase
Function interconversion of glucose 6-phosphate and alpha-glucose 1-phosphate
Metabolic function and regulation of this protein in SubtiPathways:
Lipid synthesis
MW, pI 62 kDa, 4.913
Gene length, protein length 1695 bp, 565 aa
Immediate neighbours glpD, yhcY
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YhxB context.gif
This image was kindly provided by SubtiList









Categories containing this gene/protein

cell wall synthesis, lipid metabolism/ other, phosphoproteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU09310

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate (according to Swiss-Prot)
  • Protein family: phosphohexose mutase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylated on ser/ thr/ tyr PubMed, PubMed
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [2]

Additional information

PgcA inhibits FtsZ ring assembly (indirect effect due to a defect in UDP-glucose synthesis)PubMed

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Massimiliano Marvasi, Pieter T Visscher, Lilliam Casillas Martinez
Exopolymeric substances (EPS) from Bacillus subtilis: polymers and genes encoding their synthesis.
FEMS Microbiol Lett: 2010, 313(1);1-9
[PubMed:20735481] [WorldCat.org] [DOI] (I p)

Original publications