Difference between revisions of "MecA"
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| + | = [[Categories]] containing this gene/protein = | ||
| + | {{SubtiWiki category|[[genetic competence]]}}, | ||
| + | {{SubtiWiki category|[[proteolysis]]}} | ||
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| + | = This gene is a member of the following [[regulons]] = | ||
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=The gene= | =The gene= | ||
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=The protein= | =The protein= | ||
Revision as of 18:29, 8 December 2010
- Description: negative regulator of competence, targets ComK to ClpC-ClpP degradation machine (in log Phase)
| Gene name | mecA |
| Synonyms | |
| Essential | no |
| Product | adaptor protein |
| Function | control of ComK degradation, regulation of competence |
| MW, pI | 25 kDa, 4.209 |
| Gene length, protein length | 654 bp, 218 aa |
| Immediate neighbours | yjbE, coiA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
genetic competence, proteolysis
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU11520
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: mecA family (according to Swiss-Prot)
- Paralogous protein(s): YpbH
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
Database entries
- UniProt: P37958
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Janine Kirstein, Noël Molière, David A Dougan, Kürşad Turgay
Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases.
Nat Rev Microbiol: 2009, 7(8);589-99
[PubMed:19609260]
[WorldCat.org]
[DOI]
(I p)
Original Publications
