Difference between revisions of "ComC"
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=== Additional information=== | === Additional information=== | ||
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=The protein= | =The protein= | ||
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* '''Interactions:''' | * '''Interactions:''' | ||
| + | ** [[ComC]]-[[ComGC]] {{PubMed|15083159}} | ||
| + | ** [[ComC]]-[[ComGD]] {{PubMed|15083159}} | ||
| + | ** [[ComC]]-[[ComGE]] {{PubMed|15083159}} | ||
| + | ** [[ComC]]-[[ComGG]] {{PubMed|15083159}} | ||
* '''Localization:''' cell membrane (according to Swiss-Prot) | * '''Localization:''' cell membrane (according to Swiss-Prot) | ||
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=References= | =References= | ||
| − | + | ==Reviews== | |
| + | <pubmed> 15083159 </pubmed> | ||
| + | ==Original publications== | ||
<pubmed>9723928,16751195,7783624,2553669,1694528, 8196543 </pubmed> | <pubmed>9723928,16751195,7783624,2553669,1694528, 8196543 </pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 15:11, 8 April 2011
- Description: late competence gene required for processing and translocation of ComGC, ComGD, ComGE and ComGG PubMed
| Gene name | comC |
| Synonyms | |
| Essential | no |
| Product | processing protease |
| Function | genetic transformation |
| Metabolic function and regulation of this protein in SubtiPathways: Protein secretion | |
| MW, pI | 26 kDa, 9.843 |
| Gene length, protein length | 744 bp, 248 aa |
| Immediate neighbours | spoIIB, folC |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
genetic competence, protein secretion, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU28070
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Typically cleaves a -Gly-|-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine (according to Swiss-Prot)
- Protein family: peptidase A24 family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P15378
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: comC PubMed
- Regulation:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Inês Chen, David Dubnau
DNA uptake during bacterial transformation.
Nat Rev Microbiol: 2004, 2(3);241-9
[PubMed:15083159]
[WorldCat.org]
[DOI]
(P p)
Original publications
