NagR

• Description: transcriptional regulator (GntR family)
  
  

Gene name	nagR
Synonyms	yvoA
Essential	no
Product	transcriptional regulator (GntR family)
Function	probably regulator of the putative nagA-nagB-yvoA operon
Metabolic function and regulation of this protein in SubtiPathways: Sugar catabolism, Murein recycling
MW, pI	27 kDa, 6.768
Gene length, protein length	729 bp, 243 aa
Immediate neighbours	nagB, yvnB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

utilization of specific carbon sources, transcription factors and their control

This gene is a member of the following regulons

NagR regulon

The NagR regulon:

• nagA-nagB-nagR, nagP

The gene

Basic information

• Locus tag: BSU35030

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: transcription repression of nagP and of the putative nagA-nagB-nagR operon in the absence of N-acetylglycosamine PubMed, weak repression of yflG PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information: K(D) for N-acetylglucosamine-6-phosphate: 1 mM PubMed

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:
  • N-acetylglucosamine-6-phosphate acts as the molecular inducer PubMed
  • glucosamine-6-phosphate acts as the molecular inducerPubMed

• Interactions:

• Localization:

Database entries

• Structure: 2WVO PubMed

• UniProt: O34817

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: nagA-nagB-nagR PubMed

• Sigma factor:

• Regulation:
  • induced in the presence of N-acetylglucosamine (NagR) PubMed

• Regulatory mechanism:
  • NagR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed