Difference between revisions of "ZnuA"

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m (moved YcdH to ZnuA: 21813502)
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|style="background:#ABCDEF;" align="center"|'''Function''' || zinc uptake
 
|style="background:#ABCDEF;" align="center"|'''Function''' || zinc uptake
 
|-
 
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/YcdH YcdH]
+
|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/ZnuA ZnuA]
 
|-
 
|-
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]'''
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]'''
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|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 957 bp, 319 aa  
 
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 957 bp, 319 aa  
 
|-
 
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ycdG]]'', ''[[ycdI]]''
+
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ycdG]]'', ''[[znuC]]''
 
|-
 
|-
 
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB12079&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
 
|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB12079&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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===Phenotypes of a mutant ===
 
===Phenotypes of a mutant ===
 
+
** reduced genetic competence, can be rescued by the addition of excess zinc {{PubMed|21813502}}
 +
** reduced expression of the ''[[comFA]]-[[comFB]]-[[comFC]]-[[yvyF]]-[[flgM]]-[[yvyG]]-[[flgK]]-[[flgL]]'' operon  {{PubMed|21813502}}
 
=== Database entries ===
 
=== Database entries ===
  
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=== Additional information===
 
=== Additional information===
 
 
  
  
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* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
  
* '''Interactions:''' [[YcdI]]-[[YceA]]-[[YcdH]] {{PubMed|10092453}}
+
* '''Interactions:''' [[ZnuA]]-[[ZnuB]]-[[ZnuC]] {{PubMed|10092453}}
  
 
* '''Localization:'''  
 
* '''Localization:'''  
** associated to the membrane (via [[YceA]]) {{PubMed|10092453,18763711}}
+
** associated to the membrane (via [[ZnuB]]) {{PubMed|10092453,18763711}}
 
** extracellular (signal peptide) [http://www.ncbi.nlm.nih.gov/pubmed/18957862 PubMed]
 
** extracellular (signal peptide) [http://www.ncbi.nlm.nih.gov/pubmed/18957862 PubMed]
  
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=Expression and regulation=
 
=Expression and regulation=
  
* '''Operon:''' ''[[ycdH]]-[[ycdI]]-[[yceA]]'' {{PubMed|9811636}}
+
* '''Operon:''' ''[[znuA]]-[[znuC]]-[[znuB]]'' {{PubMed|9811636}}
  
 
* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|12426338}}
 
* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|12426338}}
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=References=
 
=References=
  
<pubmed>12426338,9811636,10092453,,12426338,18957862 18763711, </pubmed>
+
<pubmed>12426338,9811636,10092453, 21813502,12426338,18957862 18763711, </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 11:20, 5 August 2011

Gene name ycdH
Synonyms
Essential no
Product ABC transporter for zinc (binding protein)
Function zinc uptake
Interactions involving this protein in SubtInteract: ZnuA
Metabolic function and regulation of this protein in SubtiPathways:
Stress
MW, pI 35 kDa, 5.146
Gene length, protein length 957 bp, 319 aa
Immediate neighbours ycdG, znuC
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YcdH context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

ABC transporters, trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), membrane proteins

This gene is a member of the following regulons

Zur regulon

The gene

Basic information

  • Locus tag: BSU02850

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: bacterial solute-binding protein 9 family (according to Swiss-Prot)
  • Paralogous protein(s): MntA

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization:
    • associated to the membrane (via ZnuB) PubMed
    • extracellular (signal peptide) PubMed

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
    • Zur: transcription repression in the presence of zinc PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References