PhrE

• Description: response regulator aspartate phosphatase (RapE) regulator, control of the phosphorelay
  
  

Gene name	phrE
Synonyms
Essential	no
Product	phosphatase (RapE) regulator
Function	control of sporulation initiation
Interactions involving this protein in SubtInteract: PhrE
Function and regulation of this protein in SubtiPathways: Phosphorelay
MW, pI	4 kDa, 8.863
Gene length, protein length	132 bp, 44 aa
Immediate neighbours	rapE, yqzI
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

phosphorelay, quorum sensing, Skin element, short peptides

This gene is a member of the following regulons

AbrB regulon, CcpA regulon, CodY regulon, ComA regulon, SigH regulon

The gene

Basic information

• Locus tag: BSU25840

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Additional information

• A mutation was found in this gene after evolution under relaxed selection for sporulation PubMed

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: phr family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O32025

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • rapE-phrE PubMed
  • phrE PubMed

• Sigma factor:
  • phrE: SigA PubMed, SigH PubMed

• Regulation: repressed by glucose (10-fold) (CcpA) PubMed
  • repressed during growth in the presence of branched chain amino acids (CodY) PubMed
  • ComA: transcription activation PubMed

• Regulatory mechanism:
  • CcpA: transcription repression
  • CodY: transcription repression PubMed
  • AbrB: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed