AccD

• Description: acetyl-CoA carboxylase (beta subunit)
  
  

Gene name	accD
Synonyms	yttI
Essential	yes PubMed
Product	acetyl-CoA carboxylase (beta subunit))
Function	production of malonyl-CoA, the substrate for fatty acid biosynthesis
Gene expression levels in SubtiExpress: accD
Interactions involving this protein in SubtInteract: AccD
Metabolic function and regulation of this protein in SubtiPathways: Lipid synthesis
MW, pI	28 kDa, 5.344
Gene length, protein length	786 bp, 262 aa
Immediate neighbours	accA, ytsJ
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis of lipids, essential genes, phosphoproteins

This gene is a member of the following regulons

Spo0A regulon

The gene

Basic information

• Locus tag: BSU29210

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:
  • phosphorylated on Arg-205 PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • (AccA-AccD)-AccB-AccC (acetyl-CoA carboxylase complex)

• Localization: Membrane-proximal (Spotty) PubMed Membrane-proximal (Spotty) PubMed

Database entries

• Structure: 1OD2 (carboxytransferase from yeast, equivalent to AccA-AccD) PubMed

• UniProt: C0SP93

• KEGG entry: [3]

• E.C. number: 6.4.1.2

Expression and regulation

• Operon: accD-accA PubMed

• Expression browser: accD PubMed

• Sigma factor:

• Regulation:
  • expressed under conditions that trigger sporulation (Spo0A) PubMed

• Regulatory mechanism:
  • Spo0A: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Stephen W White, Jie Zheng, Yong-Mei Zhang, Rock
The structural biology of type II fatty acid biosynthesis.
Annu Rev Biochem: 2005, 74;791-831
[PubMed:15952903] [WorldCat.org] [DOI] (P p)