Difference between revisions of "MleN"
(→Expression and regulation) |
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= This gene is a member of the following [[regulons]] = | = This gene is a member of the following [[regulons]] = | ||
| + | {{SubtiWiki regulon|[[AnsR regulon]]}}, | ||
{{SubtiWiki regulon|[[CcpA regulon]]}} | {{SubtiWiki regulon|[[CcpA regulon]]}} | ||
| Line 111: | Line 112: | ||
* '''Sigma factor:''' | * '''Sigma factor:''' | ||
| + | ** ''[[ansA]]'': [[SigA]] {{PubMed|1711029}} | ||
** ''[[mleN]]'': [[SigA]] {{PubMed|22900538}} | ** ''[[mleN]]'': [[SigA]] {{PubMed|22900538}} | ||
* '''Regulation:''' | * '''Regulation:''' | ||
| − | ** repressed by glucose ([[CcpA]]) {{PubMed|22900538}} | + | ** ''[[ansA]]'': expressed in the presence of asparagine ([[AnsR]]) {{PubMed|11914346}} |
| + | ** ''[[mleN]]'': repressed by glucose ([[CcpA]]) {{PubMed|22900538}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| + | ** [[AnsR]]: transcription repression {{PubMed|11914346}} | ||
** [[CcpA]]: transcription repression {{PubMed|22900538}} | ** [[CcpA]]: transcription repression {{PubMed|22900538}} | ||
| Line 141: | Line 145: | ||
=References= | =References= | ||
| − | <pubmed>18763711, 10903309 22900538</pubmed> | + | <pubmed>18763711, 10903309 22900538 22383849 1711029 11914346</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 16:12, 23 August 2012
- Description: malate-H+/Na+-lactate antiporter
| Gene name | mleN |
| Synonyms | yqkI |
| Essential | no |
| Product | malate-H+/Na+-lactate antiporter |
| Function | malate uptake |
| Gene expression levels in SubtiExpress: mleN | |
| Metabolic function and regulation of this protein in SubtiPathways: Central C-metabolism | |
| MW, pI | 50 kDa, 7.249 |
| Gene length, protein length | 1404 bp, 468 aa |
| Immediate neighbours | mleA, ansB |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
transporters/ other, utilization of specific carbon sources, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU23560
Phenotypes of a mutant
abrupt arrest in the mid-logarithmic phase of growth on malate when low concentrations of protonophore were present PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: nhaC Na(+)/H(+) antiporter family (according to Swiss-Prot)
- Paralogous protein(s): NhaC
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
- membrane associated PubMed
Database entries
- Structure:
- UniProt: P54571
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
