UxuA

• Description: D-mannonate hydrolyase
  
  

Gene name	uxuA
Synonyms	yjmE
Essential	no
Product	D-mannonate hydrolyase
Function	hexuronate utilization
Gene expression levels in SubtiExpress: uxuA
MW, pI	40 kDa, 4.92
Gene length, protein length	1077 bp, 359 aa
Immediate neighbours	yjmD, yjmF
Sequences	Protein DNA Advanced_DNA
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

utilization of specific carbon sources, sporulation proteins

This gene is a member of the following regulons

CcpA regulon, ExuR regulon, SigE regulon

The gene

Basic information

• Locus tag: BSU12340

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H₂O (according to Swiss-Prot)

• Protein family: mannonate dehydratase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O34346

• KEGG entry: [3]

• E.C. number: 4.2.1.8

Expression and regulation

• Operon:
  • uxaC-yjmB-yjmC-yjmD-uxuA-yjmF-exuT-exuR-uxaB-uxaA PubMed
  • yjmC-yjmD-uxuA-yjmF-exuT-exuR-uxaB-uxaA PubMed

• Expression browser: uxuA PubMed

• Sigma factor: SigE PubMed
  • uxaC: SigA PubMed
  • yjmC: SigE PubMed

• Regulation:
  • repressed by glucose (CcpA) PubMed1 PubMed2
  • induced by galacturonate (ExuR) PubMed

• Regulatory mechanism:
  • CcpA: transcription repression PubMed1 PubMed2
  • ExuR: reanscription repression in the absence of inducer PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: