Difference between revisions of "PyrG"
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=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU37150&redirect=T BSU37150] | ||
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/pyrG.html] | * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/pyrG.html] | ||
| Line 98: | Line 99: | ||
=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU37150&redirect=T BSU37150] | ||
* '''Structure:''' [http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1VCM 1VCM] (from ''Thermus thermophilus'', 52% identity, 70% similarity) {{PubMed|15296735}} | * '''Structure:''' [http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1VCM 1VCM] (from ''Thermus thermophilus'', 52% identity, 70% similarity) {{PubMed|15296735}} | ||
Revision as of 15:03, 2 April 2014
- Description: CTP synthase (NH3, glutamine)
| Gene name | pyrG |
| Synonyms | ctrA |
| Essential | yes PubMed |
| Product | CTP synthase (NH3, glutamine) |
| Function | pyrimidine biosynthesis |
| Gene expression levels in SubtiExpress: pyrG | |
| Metabolic function and regulation of this protein in SubtiPathways: pyrG | |
| MW, pI | 59 kDa, 5.16 |
| Gene length, protein length | 1605 bp, 535 aa |
| Immediate neighbours | ywjG, rpoE |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
biosynthesis/ acquisition of nucleotides, essential genes
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU37150
Phenotypes of a mutant
essential PubMed
Database entries
- BsubCyc: BSU37150
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: ATP + UTP + NH3 = ADP + phosphate + CTP (according to Swiss-Prot)
- Protein family: CTP synthase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- BsubCyc: BSU37150
- UniProt: P13242
- KEGG entry: [3]
- E.C. number: 6.3.4.2
Additional information
Expression and regulation
- Operon: pyrG PubMed
- Regulation:
- repressed by cytidine nucleotides (RNA switch) PubMed
- Regulatory mechanism:
- RNA switch: transcription (termination in the presence of cytidine nucleotides) PubMed
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Charles L Turnbough
Regulation of gene expression by reiterative transcription.
Curr Opin Microbiol: 2011, 14(2);142-7
[PubMed:21334966]
[WorldCat.org]
[DOI]
(I p)
Charles L Turnbough, Robert L Switzer
Regulation of pyrimidine biosynthetic gene expression in bacteria: repression without repressors.
Microbiol Mol Biol Rev: 2008, 72(2);266-300, table of contents
[PubMed:18535147]
[WorldCat.org]
[DOI]
(I p)
Original publications
