YloS

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  • Description: thiamine pyrophosphokinase

Gene name yloS
Synonyms thiN
Essential no
Product thiamine pyrophosphokinase
Function thiamine salvage
MW, pI 23 kDa, 5.216
Gene length, protein length 642 bp, 214 aa
Immediate neighbours rpe, spoVM
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YloS context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU15800

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + thiamine = AMP + thiamine diphosphate (according to Swiss-Prot)
  • Protein family: thiamine pyrophosphokinase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure: 3CQ9 (from Lactobacillus plantarum, 38% identity, 55% similarity)
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Christopher T Jurgenson, Tadhg P Begley, Steven E Ealick
The structural and biochemical foundations of thiamin biosynthesis.
Annu Rev Biochem: 2009, 78;569-603
[PubMed:19348578] [WorldCat.org] [DOI] (I p)

Original publications