FolC

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  • Description: folyl-polyglutamate synthetase

Gene name folC
Synonyms
Essential no
Product folyl-polyglutamate synthetase
Function biosynthesis of folate
Metabolic function and regulation of this protein in SubtiPathways:
tRNA charging, Folate
MW, pI 48 kDa, 5.806
Gene length, protein length 1290 bp, 430 aa
Immediate neighbours comC, valS
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
FolC context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

biosynthesis of cofactors, membrane proteins

This gene is a member of the following regulons

T-box

The gene

Basic information

  • Locus tag: BSU28080

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1) (according to Swiss-Prot)
  • Protein family: folylpolyglutamate synthase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1FGS (from Lactobacillus casei, 32% identity, 51% similarity) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Ana Gutiérrez-Preciado, Tina M Henkin, Frank J Grundy, Charles Yanofsky, Enrique Merino
Biochemical features and functional implications of the RNA-based T-box regulatory mechanism.
Microbiol Mol Biol Rev: 2009, 73(1);36-61
[PubMed:19258532] [WorldCat.org] [DOI] (I p)

Original Publications