ComC
Revision as of 14:31, 7 August 2012 by 134.76.70.252 (talk)
- Description: late competence gene required for processing and translocation of ComGC, ComGD, ComGE and ComGG PubMed
Gene name | comC |
Synonyms | |
Essential | no |
Product | processing protease |
Function | genetic competence |
Gene expression levels in SubtiExpress: comC | |
Interactions involving this protein in SubtInteract: ComC | |
Metabolic function and regulation of this protein in SubtiPathways: Protein secretion | |
MW, pI | 26 kDa, 9.843 |
Gene length, protein length | 744 bp, 248 aa |
Immediate neighbours | spoIIB, folC |
Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context This image was kindly provided by SubtiList
| |
Expression at a glance PubMed |
Contents
Categories containing this gene/protein
genetic competence, protein secretion, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU28070
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- processing and translocation of ComGC, ComGD, ComGE and ComGG PubMed
- Typically cleaves a -Gly-|-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine (according to Swiss-Prot)
- Protein family: peptidase A24 family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P15378
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: comC PubMed
- Regulation:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Inês Chen, David Dubnau
DNA uptake during bacterial transformation.
Nat Rev Microbiol: 2004, 2(3);241-9
[PubMed:15083159]
[WorldCat.org]
[DOI]
(P p)
Original publications