ComC

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Gene name comC
Synonyms
Essential no
Product processing protease
Function genetic competence
Gene expression levels in SubtiExpress: comC
Interactions involving this protein in SubtInteract: ComC
Metabolic function and regulation of this protein in SubtiPathways:
Protein secretion
MW, pI 26 kDa, 9.843
Gene length, protein length 744 bp, 248 aa
Immediate neighbours spoIIB, folC
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
ComC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
ComC expression.png


























Categories containing this gene/protein

genetic competence, protein secretion, membrane proteins

This gene is a member of the following regulons

ComK regulon

The gene

Basic information

  • Locus tag: BSU28070

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • processing and translocation of ComGC, ComGD, ComGE and ComGG PubMed
    • Typically cleaves a -Gly-|-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine (according to Swiss-Prot)
  • Protein family: peptidase A24 family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Inês Chen, David Dubnau
DNA uptake during bacterial transformation.
Nat Rev Microbiol: 2004, 2(3);241-9
[PubMed:15083159] [WorldCat.org] [DOI] (P p)

Original publications