YqeH

• Description: assembly/ stability of the 30S subunit of the ribosome, assembly of the 70S ribosome
  
  

Gene name	yqeH
Synonyms
Essential	yes PubMed
Product	GTPase
Function	ribosome assembly
Gene expression levels in SubtiExpress: yqeH
MW, pI	40 kDa, 6.009
Gene length, protein length	1098 bp, 366 aa
Immediate neighbours	aroD, yqeG
Sequences	Protein DNA Advanced_DNA
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

translation, essential genes, GTP-binding proteins

The gene

Basic information

• Locus tag: BSU25670

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Binds and hydrolyzes GTP and readily exchanges GDP for GTP

• Protein family: Era/Obg family

• Paralogous protein(s): Era, Obg, YphC, YsxC, RbgA, YqeH, ThdF, YyaF, YnbA

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 3EC1 (Geobacillus stearothermophilus)

• UniProt: P54453

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: yqeH PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Naotake Ogasawara, Nara, Japan

References

Original publications

Baskaran Anand, Parag Surana, Balaji Prakash
Deciphering the catalytic machinery in 30S ribosome assembly GTPase YqeH.
PLoS One: 2010, 5(4);e9944
[PubMed:20376346] [WorldCat.org] [DOI] (I e)

Baskaran Anand, Parag Surana, Sagar Bhogaraju, Sushmita Pahari, Balaji Prakash
Circularly permuted GTPase YqeH binds 30S ribosomal subunit: Implications for its role in ribosome assembly.
Biochem Biophys Res Commun: 2009, 386(4);602-6
[PubMed:19540197] [WorldCat.org] [DOI] (I p)

Pek Chin Loh, Takuya Morimoto, Yoshitaka Matsuo, Taku Oshima, Naotake Ogasawara
The GTP-binding protein YqeH participates in biogenesis of the 30S ribosome subunit in Bacillus subtilis.
Genes Genet Syst: 2007, 82(4);281-9
[PubMed:17895579] [WorldCat.org] [DOI] (P p)

William C Uicker, Laura Schaefer, Mark Koenigsknecht, Robert A Britton
The essential GTPase YqeH is required for proper ribosome assembly in Bacillus subtilis.
J Bacteriol: 2007, 189(7);2926-9
[PubMed:17237168] [WorldCat.org] [DOI] (P p)

Takuya Morimoto, Pek Chin Loh, Tomohiro Hirai, Kei Asai, Kazuo Kobayashi, Shigeki Moriya, Naotake Ogasawara
Six GTP-binding proteins of the Era/Obg family are essential for cell growth in Bacillus subtilis.
Microbiology (Reading): 2002, 148(Pt 11);3539-3552
[PubMed:12427945] [WorldCat.org] [DOI] (P p)