FtsL

• Description: cell-division protein (septum formation), controls together with EzrA dynamics of the FtsZ ring
  
  

Gene name	ftsL
Synonyms	ylxB, yllD
Essential	yes PubMed
Product	cell-division protein
Function	septum formation
Gene expression levels in SubtiExpress: ftsL
Interactions involving this protein in SubtInteract: FtsL
MW, pI	12 kDa, 10.083
Gene length, protein length	351 bp, 117 aa
Immediate neighbours	mraW, pbpB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell division, essential genes, membrane proteins

The gene

Basic information

• Locus tag: BSU15150

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ftsL family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: degraded by RasP, stabilized against RasP cleavage by DivIC PubMed

• Interactions:
  • RasP-FtsL, DivIC-FtsL PubMed
  • PbpB-DivIB-(FtsL-DivIC)2 PubMed, as part of the divisome
  • WalK-FtsL PubMed

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: Q07867

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: mraZ-mraW-ftsL-pbpB PubMed

• Expression browser: ftsL PubMed

• Sigma factor:

• Regulation:
  • constitutively expressed PubMed

• Regulatory mechanism:

• Additional information: FtsL is degraded by RasP PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Gu Chen, Xu Zhang
New insights into S2P signaling cascades: regulation, variation, and conservation.
Protein Sci: 2010, 19(11);2015-30
[PubMed:20836086] [WorldCat.org] [DOI] (I p)