GreA
- Description: transcription elongation factor, resolves stalled RNA polymerase at promoter or promoter-proximal regions,
| Gene name | greA |
| Synonyms | |
| Essential | no |
| Product | transcription elongation factor |
| Function | transcription elongation |
| MW, pI | 17 kDa, 4.475 |
| Gene length, protein length | 471 bp, 157 aa |
| Immediate neighbours | pbpI, udk |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU27320
Phenotypes of a mutant
- RNA polymerase accumulates in promoter-proximal regions of many genes PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: greA/greB family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions: GreA-RNA polymerase PubMed
- Localization: uniformly distributed throughout the nucleoid PubMed
Database entries
- Structure:
- UniProt: P80240
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Original Publications
Yoko Kusuya, Ken Kurokawa, Shu Ishikawa, Naotake Ogasawara, Taku Oshima
Transcription factor GreA contributes to resolving promoter-proximal pausing of RNA polymerase in Bacillus subtilis cells.
J Bacteriol: 2011, 193(12);3090-9
[PubMed:21515770]
[WorldCat.org]
[DOI]
(I p)
Mohammad Roghanian, Yulia Yuzenkova, Nikolay Zenkin
Controlled interplay between trigger loop and Gre factor in the RNA polymerase active centre.
Nucleic Acids Res: 2011, 39(10);4352-9
[PubMed:21266474]
[WorldCat.org]
[DOI]
(I p)
Geoff P Doherty, Donna H Meredith, Peter J Lewis
Subcellular partitioning of transcription factors in Bacillus subtilis.
J Bacteriol: 2006, 188(11);4101-10
[PubMed:16707701]
[WorldCat.org]
[DOI]
(P p)
