Glutamate metabolism

Proteins involved in glutamate metabolism

Transport systems

• Ammonium uptake: AmtB
• Glutamine uptake: GlnT, GlnQ-(GlnM-GlnP)-GlnH
• Glutamate uptake: GltT

Metabolic enzymes

• Glutamine synthetase: GlnA
• Glutamate synthase: GltA, GltB
• Glutamate dehydrogenases: GudB, RocG

Regulators

• Key transcriptional regulators of nitrogen metabolism: GlnR, GltC, TnrA
• Additional transcriptional regulators: AhrC, RocR, CcpA, Fur
• Control of ammonium uptake: GlnK

Relevant SubtiWiki pages

• Biosynthesis/ acquisition of amino acids
• Utilization of amino acids
• TnrA regulon
• GlnR regulon
• GltC regulon
• Trigger enzymes

Additional websites

• transcriptome analysis of a rocG gudB mutant vs. wild type

Labs studying glutamate metabolism

• Fabian Commichau, Göttingen, Germany
• Susan Fisher, Boston
• Linc Sonenshein, Boston
• Jörg Stülke, Göttingen

Important publications

Reviews

Gunka K, Commichau FM    
Control of glutamate homeostasis in Bacillus subtilis: 
a complex interplay between ammonium assimilation,  
glutamate biosynthesis and degradation.  
Mol Microbiol.: 2012, 85(2) 213-224. 
PubMed:22625175