LicB

• Description: trigger enzyme: lichenan-specific phosphotransferase system, EIIB component of the PTS
  
  

Gene name	licB
Synonyms	celA
Essential	no
Product	trigger enzyme: lichenan-specific phosphotransferase system, EIIB component
Function	lichenan uptake and phosphorylation, control of LicR activity
Gene expression levels in SubtiExpress: licB
Interactions involving this protein in SubtInteract: LicB
Metabolic function and regulation of this protein in SubtiPathways: Sugar catabolism
MW, pI	10 kDa, 6.314
Gene length, protein length	306 bp, 102 aa
Immediate neighbours	licC, licR
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

phosphotransferase systems, utilization of specific carbon sources, transcription factors and their control, trigger enzyme, phosphoproteins

This gene is a member of the following regulons

CcpA regulon, LicR regulon

The gene

Basic information

• Locus tag: BSU38590

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate (according to Swiss-Prot)

• Protein family: PTS permease, lactose permease (Lac) family PubMed

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylation on Ser-37 PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • LicA-LicB, LicB-LicC, LicB-LicR

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P46318

• KEGG entry: [2]

• E.C. number: 2.7.1.69 9

Expression and regulation

• Operon: licB-licC-licA-licH PubMed

• Expression browser: licB PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • carbon catabolite repression (CcpA) PubMed
  • induction by oligomeric ß-glucosides (LicR)PubMed

• Regulatory mechanism:
  • CcpA: transcription repression PubMed
  • LicR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: