DesR

• Description: two-component response regulator, regulation of cold shock expression of des
  
  

Gene name	desR
Synonyms	yocG
Essential	no
Product	two-component response regulator
Function	regulation of cold shock expression of des
Metabolic function and regulation of this protein in SubtiPathways: Fatty acid degradation
MW, pI	22 kDa, 4.885
Gene length, protein length	597 bp, 199 aa
Immediate neighbours	desK, yocH
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

lipid metabolism/ other, transcription factors and their control, cold stress proteins, membrane proteins, phosphoproteins

The DesR regulon:

• des

The gene

Basic information

• Locus tag: BSU19200

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: transcription activation of the des operon when phosphorylated by DesK

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylated by DesK on an Asp residue

• Cofactor(s):

• Effectors of protein activity:

• Interactions: DesK-DesR

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: O34723

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: desK-desR PubMed

• Sigma factor:

• Regulation:
  • induced by cold shock (18-fold) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

• Diego de Mendoza, Universidad Nacional de Rosario, Argentine homepage