Sr1

• Description: small regulatory RNA controlling ahrC expression, peptide controlling the stability of the cggR-gapA mRNA
  
  

Gene name	sr1
Synonyms	ykzW
Essential	no
Product	small regulatory RNA/ regulatory peptide
Function	control of arginine metabolism and glycolysis
MW, pI	4.4 kDa, 3.89
Gene length, protein length	205 bp (RNA), 120 bp (ORF), 39 aa
Immediate neighbours	slp, speA
Gene sequence
Genetic context

Categories containing this gene/protein

biosynthesis/ acquisition of amino acids, utilization of amino acids, ncRNA

This gene is a member of the following regulons

CcpN regulon

The gene

Basic information

• Locus tag:

Database entries

• DBTBS entry: no entry

Additional information

Located between the slp and speA genes.

The RNA

Basic information/ Evolution

• Catalyzed reaction/ biological activity: hybridizes to ahrC mRNA and inhibits AhrC translation. PubMed

Extended information on the RNA

• Kinetic information

• Interactions: Binds ahrC mRNA PubMed

• Localization

Database entries

• Structure:

Additional information

Information on the structure of the RNA can be found in Heidrich et al., 2006

The peptide

Basic information/ Evolution

• Catalyzed reaction/ biological activity: the peptide controls the stability of the cggR-gapA mRNA PubMed

• Protein family: the peptide is conserved in bacilli

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • GapA-YkzW PubMed

• Localization:

Database entries

• Structure:

• UniProt: C0H410

• KEGG entry:

• E.C. number:

Expression and regulation

• Operon: sr1 PubMed

• Sigma factor: SigA PubMed

• Regulation: Repressed in the presence of glucose by CcpN PubMed

• Regulatory mechanism: transcription repression PubMed

• Additional information:

Biological materials

• Mutant: 168 sr1::cat, available in Brantl lab

• Expression vector:

• lacZ fusion:

Labs working on this gene/protein

Sabine Brantl, Bacterial Genetics, Friedrich-Schiller-University of Jena, Germany homepage