NrdF
- Description: ribonucleoside-diphosphate reductase (major subunit)
| Gene name | nrdF |
| Synonyms | |
| Essential | yes PubMed |
| Product | ribonucleoside-diphosphate reductase (major subunit) |
| Function | synthesis of deoxyribonucleoside triphosphates |
| Interactions involving this protein in SubtInteract: NrdF | |
| Metabolic function and regulation of this protein in SubtiPathways: Purine salvage, Nucleotides (regulation) | |
| MW, pI | 38 kDa, 4.66 |
| Gene length, protein length | 987 bp, 329 aa |
| Immediate neighbours | nrdE, ymaB |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
biosynthesis/ acquisition of nucleotides, essential genes
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU17390
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin (according to Swiss-Prot)
- Protein family: ribonucleoside diphosphate reductase small chain family (according to Swiss-Prot)
- Paralogous protein(s): YosP
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s): Mn(2+) PubMed
- Effectors of protein activity:
- Localization:
Database entries
- Structure:
- UniProt: P50621
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Elisabeth Härtig, Braunschweig, Germany Homepage
Your additional remarks
References
Reviews
Original Publications
Additional publications: PubMed
