YodB

• Description: MarR/DUF24 family transcription repressor of azoR1, catD-catE and yodC expression
  
  

Gene name	yodB
Synonyms
Essential	no
Product	MarR/DUF24 family transcription repressor
Function	regulation of quinone and diamide detoxification
MW, pI	12 kDa, 4.737
Gene length, protein length	336 bp, 112 aa
Immediate neighbours	yodA, yodC
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

transcription factors and their control, resistance against oxidative and electrophile stress

This gene is a member of the following regulons

YodB regulon

The YodB regulon:

• azoR1, catD-catE, yodB, yodC

The gene

Basic information

• Locus tag: BSU19540

Phenotypes of a mutant

• increased resistance to catechol, quinones and diamide PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

Additional information

Expression

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: MarR/DUF24 family

• Paralogous protein(s): CatR

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: redox-controlled by intersubunit disulfide formation of Cys6 and Cys101' in response to quinones and diamide

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O34844

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:
  • subject to autorepression PubMed

• Regulatory mechanism:
  • YodB: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Haike Antelmann,University of Greifswald, Germany

References

Reviews

Antelmann H, Helmann JD.
Thiol-based redox switches and gene regulation.
Antioxid Redox Signal. 2011,14:1049-63.
PubMed