PgsA

• Description: phosphatidylglycerophosphate synthase
  
  

Gene name	pgsA
Synonyms	ymfN
Essential	yes PubMed
Product	phosphatidylglycerophosphate synthase
Function	biosynthesis of phospholipids
Metabolic function and regulation of this protein in SubtiPathways: Lipid synthesis
MW, pI	21 kDa, 5.163
Gene length, protein length	579 bp, 193 aa
Immediate neighbours	rodZ, cinA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

biosynthesis of lipids, essential genes, membrane proteins

The gene

Basic information

• Locus tag: BSU16920

Phenotypes of a mutant

• some point mutations resulting in reduced PgsA activity lead to daptomycin resistance PubMed

essential PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate (according to Swiss-Prot)

• Protein family: CDP-alcohol phosphatidyltransferase class-I family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane at the septum PubMed

Database entries

• Structure:

• UniProt: P46322

• KEGG entry: [2]

• E.C. number: 2.7.8.5

Expression and regulation

• Operon:

• Expression browser: pgsA PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: