DctP

• Description: uptake of succinate, fumurate, malate and oxaloacetate via proton symport
  
  

Gene name	dctP
Synonyms	ydbH, dctA
Essential	no
Product	C4-dicarboxylate transport protein
Function	uptake of succinate, fumurate, malate and oxaloacetate
Gene expression levels in SubtiExpress: dctP
Metabolic function and regulation of this protein in SubtiPathways: Central C-metabolism
MW, pI	45 kDa, 8.668
Gene length, protein length	1263 bp, 421 aa
Immediate neighbours	dctR, ydbI
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transporters/ other, utilization of specific carbon sources, membrane proteins

This gene is a member of the following regulons

CcpA regulon, FsrA regulon

The gene

Basic information

• Locus tag: BSU04470

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: uptake of succinate, fumurate, malate and oxaloacetate via proton symport PubMed

• Protein family: View classification (according to Swiss-Prot)

• Paralogous protein(s): GltP, GltT

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P96603

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:
  • dctS-dctR-dctP PubMed
  • dctP PubMed

• Expression browser: dctP PubMed

• Sigma factor:
  • dctP: SigA PubMed

• Regulation:
  • repressed by glucose (6.2-fold) (CcpA) PubMed
  • part of the iron sparing response, strong down-regulation in a fur mutant (Fur, FsrA) PubMed

• Regulatory mechanism:
  • CcpA: transcription repression PubMed
  • Fur: indirect effect via control of fsrA expression PubMed
  • FsrA: translation inhibition PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: